Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/100173
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dc.contributor.authorLawson, M.en
dc.contributor.authorMcDonald, M.en
dc.contributor.authorKovacic, N.en
dc.contributor.authorKhoo, W.en
dc.contributor.authorTerry, R.en
dc.contributor.authorDown, J.en
dc.contributor.authorKaplan, W.en
dc.contributor.authorPaton-Hough, J.en
dc.contributor.authorFellows, C.en
dc.contributor.authorPettitt, J.en
dc.contributor.authorDear, T.en
dc.contributor.authorVan Valckenborgh, E.en
dc.contributor.authorBaldock, P.en
dc.contributor.authorRogers, M.en
dc.contributor.authorEaton, C.en
dc.contributor.authorVanderkerken, K.en
dc.contributor.authorPettit, A.en
dc.contributor.authorQuinn, J.en
dc.contributor.authorZannettino, A.en
dc.contributor.authorPhan, T.en
dc.contributor.authoret al.en
dc.date.issued2015en
dc.identifier.citationNature Communications, 2015; 6(1):8986-1-8986-15en
dc.identifier.issn2041-1723en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://hdl.handle.net/2440/100173-
dc.description.abstractMultiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it exerts cell-extrinsic control over myeloma cell dormancy and reactivation. In this study, we track individual myeloma cells by intravital imaging as they colonize the endosteal niche, enter a dormant state and subsequently become activated to form colonies. We demonstrate that dormancy is a reversible state that is switched 'on' by engagement with bone-lining cells or osteoblasts, and switched 'off' by osteoclasts remodelling the endosteal niche. Dormant myeloma cells are resistant to chemotherapy that targets dividing cells. The demonstration that the endosteal niche is pivotal in controlling myeloma cell dormancy highlights the potential for targeting cell-extrinsic mechanisms to overcome cell-intrinsic drug resistance and prevent disease relapse.en
dc.description.statementofresponsibilityMichelle A. Lawson, Michelle M. McDonald, Natasa Kovacic, Weng Hua Khoo, Rachael L. Terry, Jenny Down, Warren Kaplan, Julia Paton-Hough, Clair Fellows, Jessica A. Pettitt, T. Neil Dear, Els Van Valckenborgh, Paul A. Baldock, Michael J. Rogers, Colby L. Eaton, Karin Vanderkerken, Allison R. Pettit, Julian M.W. Quinn, Andrew C.W. Zannettino, Tri Giang Phan, Peter I. Croucheren
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectOsteoclasts; myeloma; endosteal nicheen
dc.titleOsteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal nicheen
dc.typeJournal articleen
dc.identifier.rmid0030040899en
dc.identifier.doi10.1038/ncomms9983en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1005097en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1057706en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/631484en
dc.identifier.pubid226476-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidZannettino, A. [0000-0002-6646-6167]en
Appears in Collections:Medicine publications

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