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Type: Journal article
Title: Aging of platelet nitric oxide signaling: pathogenesis, clinical implications, and therapeutics
Author: Procter, N.
Chong, C.
Sverdlov, A.
Chan, W.
Chirkov, Y.
Horowitz, J.
Citation: Seminars in Thrombosis and Hemostasis, 2014; 40(6):660-668
Publisher: Thieme Medical Publishers
Issue Date: 2014
ISSN: 0094-6176
Statement of
Nathan E. K. Procter, Cher-Rin Chong, Aaron L. Sverdlov, Wai Ping A. Chan, Yuliy Y. Chirkov, John D. Horowitz
Abstract: The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are "scavenging" of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.
Keywords: platelet aggregation; nitric oxide; aging; cyclic guanosine monophosphate
Rights: Copyright © 2014 by Thieme Medical Publishers, Inc.
RMID: 0030014274
DOI: 10.1055/s-0034-1389082
Appears in Collections:Medicine publications

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