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Type: Journal article
Title: Changes in fibrinogen levels in patients undergoing open and laparoscopic Nissen fundoplication
Author: Pike, G.
Bessell, J.
Mathew, G.
Watson, D.
Mitchell, P.
Jamieson, G.
Citation: ANZ Journal of Surgery, 1996; 66(2):94-96
Issue Date: 1996
ISSN: 0004-8682
Statement of
Gregory K. Pike, Justin R. Bessell, George Matthew, David I. Watson, Phillip C. Mitchell and Glyn G. Jamieson
Abstract: <h4>Background</h4>Venous thromboembolic complications may be more common after laparoscopic surgical techniques, possibly due to changes in venous flow and blood coagulability.<h4>Methods</h4>This study assessed fibrinogen, cross-linked fibrin degradation products (D-dimer), prothrombin international normalized ration (INR), activated partial thromboplastic time (APTT) and platelets, during and after both open and laparoscopic Nissen fundoplication to determine whether coagulability is increased by the laparoscopic approach.<h4>Results</h4>Seven patients underwent open and thirteen underwent laparoscopic Nissen fundoplication. Fibrinogen levels following open fundoplication fell from 2.8 +/- 0.3 g/L pre-operatively to 2.0 +/- 0.3 g/L following skin incision, and then increased to 4.1 +/- 0.4 g/L on the first postoperative day. Similar changes in fibrinogen occurred following laparoscopic fundoplication (2.7 +/- 0.2, 2.5 +/ 0.2 and 3.8 +/- 0.4 g/L, respectively). No significant changes in the other coagulation indices were observed.<h4>Conclusions</h4>These results demonstrate hypercoagulability on the first postoperative day, irrespective of the operative technique. No differences between the results following laparoscopic and open fundoplication were demonstrated.
Keywords: Humans
Gastroesophageal Reflux
Blood Coagulation Tests
Postoperative Period
Analysis of Variance
Middle Aged
Description: Copyright © 2009 Royal Australasian College of Surgeons
Provenance: Published Online: 21 Jan 2008
DOI: 10.1111/j.1445-2197.1996.tb01120.x
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Appears in Collections:Aurora harvest
Surgery publications

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