Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/100925
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Type: Journal article
Title: Review of null hypothesis significance testing in the ophthalmic literature: are most 'significant' P values false positives?
Author: Sanfilippo, P.
Casson, R.
Yazar, S.
Mackey, D.
Hewitt, A.
Citation: Clinical and Experimental Ophthalmology, 2016; 44(1):52-61
Publisher: Wiley
Issue Date: 2016
ISSN: 1442-6404
1442-9071
Statement of
Responsibility: 
Paul G Sanfilippo, Robert J Casson, Seyhan Yazar, David A Mackey and Alex W Hewitt
Abstract: P values associated with null hypothesis significance testing (NHST) are almost universal in the ophthalmic literature. A P value < 0.05 is traditionally considered 'significant'. This concept may deflect further thought about the veracity of the results. P values influence the publishability of the data and have flow-on effects for funding success and the direction of future research. Despite their importance, the problems inherent in P values have been recognized since their inception, and in more recent years have been increasingly highlighted in some scientific fields. In this review, we aim to bring the problems associated with P values and NHST to the attention of the ophthalmic research community. We do not offer a universal solution to the problem of determining the veracity of a scientific claim; however, we demonstrate the need for caution in interpreting 'significant' P values by performing a Bayesian re-analysis of t-tests in the ophthalmic literature.
Keywords: biostatistics; epidemiology; journal
Rights: © 2015 Royal Australian and New Zealand College of Ophthalmologists
RMID: 0030038368
DOI: 10.1111/ceo.12570
Appears in Collections:Opthalmology & Visual Sciences publications

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