Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/10107
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DC Field | Value | Language |
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dc.contributor.author | Johnsson, F. | - |
dc.contributor.author | Holloway, R. | - |
dc.contributor.author | Ireland, A. | - |
dc.contributor.author | Jamieson, G. | - |
dc.contributor.author | Dent, J. | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | British Journal of Surgery, 1997; 84(5):686-689 | - |
dc.identifier.issn | 0007-1323 | - |
dc.identifier.issn | 1365-2168 | - |
dc.identifier.uri | http://hdl.handle.net/2440/10107 | - |
dc.description.abstract | <h4>Background</h4>Fundoplication is used widely to treat severe gastro-oesophageal reflux disease. Difficulty in belching and increased flatulence are common side-effects. Transient lower oesophageal sphincter (LOS) relaxation is important to help vent gas from the stomach. The effect of fundoplication on LOS function and gas reflux was therefore investigated.<h4>Methods</h4>Oesophageal manometry was performed before operation and 3-15 months after fundoplication in 14 patients with reflux disease who had a total (360 degrees) fundoplication. Five patients also had highly selective vagotomy. Gastric distension was induced by 750 ml carbon dioxide.<h4>Results</h4>Fundoplication reduced the median number of episodes of gas reflux during 10 min of gastric distension from 5 (interquartile range (i.q.r.) 3-7) to 0 (i.q.r. 0), and the median number of transient LOS relaxations from 4 (i.q.r. 2-6) to 0 (i.q.r. 0-1). Fundoplication did not affect basal LOS pressure but significantly increased nadir pressure during swallow-induced relaxation.<h4>Conclusion</h4>Fundoplication controls reflux by inhibiting the triggering of transient LOS relaxation and by preventing the complete ablation of pressure at the gastro-oesophageal junction during LOS relaxation. These effects may also contribute to the side-effects of the operation. | - |
dc.language.iso | en | - |
dc.publisher | BLACKWELL SCIENCE LTD | - |
dc.source.uri | http://dx.doi.org/10.1002/bjs.1800840533 | - |
dc.subject | Esophagus | - |
dc.subject | Humans | - |
dc.subject | Gastroesophageal Reflux | - |
dc.subject | Eructation | - |
dc.subject | Gases | - |
dc.subject | Postoperative Care | - |
dc.subject | Preoperative Care | - |
dc.subject | Fundoplication | - |
dc.subject | Manometry | - |
dc.subject | Muscle Relaxation | - |
dc.subject | Pressure | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Effect of fundoplication on transient lower oesophageal sphincter relaxation and gas reflux | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/bjs.1800840533 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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