Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/101859
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dc.contributor.authorAbdul-Aziz, M.en
dc.contributor.authorCooper, A.en
dc.contributor.authorWeyrich, L.en
dc.date.issued2016en
dc.identifier.citationFrontiers in Microbiology, 2016; 7(OCT):1611-1-1611-9en
dc.identifier.issn1664-302Xen
dc.identifier.issn1664-302Xen
dc.identifier.urihttp://hdl.handle.net/2440/101859-
dc.descriptionPublished: 12 October 2016en
dc.description.abstractAs our understanding of the human microbiome expands, impacts on health and disease continue to be revealed. Alterations in the microbiome can result in dysbiosis, which has now been linked to subsequent autoimmune and metabolic diseases, highlighting the need to identify factors that shape the microbiome. Research has identified that the composition and functions of the human microbiome can be influenced by diet, age, sex, and environment. More recently, studies have explored how human genetic variation may also influence the microbiome. Here, we review several recent analytical advances in this new research area, including those that use genome-wide association studies to examine host genome–microbiome interactions, while controlling for the influence of other factors. We find that current research is limited by small sample sizes, lack of cohort replication, and insufficient confirmatory mechanistic studies. In addition, we discuss the importance of understanding long-term interactions between the host genome and microbiome, as well as the potential impacts of disrupting this relationship, and explore new research avenues that may provide information about the co-evolutionary history of humans and their microorganisms.en
dc.description.statementofresponsibilityMuslihudeen A. Abdul-Aziz, Alan Cooper and Laura S. Weyrichen
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rightsCopyright © 2016 Abdul-Aziz,Cooper and Weyrich.This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s)or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.source.urihttp://journal.frontiersin.org/en
dc.subjectmicrobiome; GWAS; ancient DNA; microbiome GWAS; model organisms; microbiota; symbiosisen
dc.titleExploring relationships between host genome and microbiome: new insights from genome-wide association studiesen
dc.typeJournal articleen
dc.identifier.rmid0030056636en
dc.identifier.doi10.3389/fmicb.2016.01611en
dc.relation.granthttp://purl.org/au-research/grants/arc/DE150101574en
dc.relation.granthttp://purl.org/au-research/grants/arc/FL140100260en
dc.identifier.pubid274009-
pubs.library.collectionAustralian Centre for Ancient DNA publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidAbdul-Aziz, M. [0000-0001-5600-0972]en
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]en
Appears in Collections:Australian Centre for Ancient DNA publications

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