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https://hdl.handle.net/2440/102356
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Type: | Journal article |
Title: | The randomized control trial of the effects of testosterone and a nutritional supplement on hospital admissions in undernourished, community dwelling, older people |
Author: | Visvanathan, R. Piantadosi, C. Lange, K. Naganathan, V. Hunter, P. Cameron, I. Chapman, I. |
Citation: | Journal of Nutrition, Health and Aging, 2016; 20(7):769-779 |
Publisher: | Springer |
Issue Date: | 2016 |
ISSN: | 1279-7707 1760-4788 |
Statement of Responsibility: | Renuka Visvanathan, C. Piantadosi, K. Lange, V. Naganathan, P. Hunter, I. D. Cameron, I. Chapman |
Abstract: | Objective: In a pilot single centre study we found that treatment of undernourished older, community dwelling people for one year with oral testosterone (placebo-controlled) and a nutritional supplement (no control) was associated with a significant reduction in hospitalizations. A larger, multicentre study was conducted to investigate further this potentially important finding. Design: One year, randomized, placebo-controlled, multicentre, double-blind, trial. Setting: Community. Participants: 53 undernourished men and women aged 65 years and older. Intervention: Oral testosterone undecanoate (40 mg/day women, 160 mg/day men) and high energy oral nutritional supplement (2108-2416 kJ/day) or placebo medication and low energy (142-191 kJ/ day) “placebo” oral nutritional supplementation. Measurements: Hospital admissions, falls and other variables were assessed. Results: 53 subjects were recruited (64% male and mean age 77 years), which was substantially less than planned. Sixteen subjects (30%) were admitted to hospital at least once, with a total of 29 admissions. Eight subjects (32%) in the placebo arm were admitted to hospital, whilst in the intervention group also there were eight (29%) subjects admitted to hospital during the study period. There was no difference in the number of hospitalisations (P = 0.842), length of hospitalization (P=0.645) or quality of life [mental health P=0.195 and physical health P=0.451) between the treatment arms. Conclusions: In undernourished older people, treatment with testosterone and a nutritional supplementation did not reduce the number and length of hospitalisations or improve quality of life. |
Keywords: | Malnutrition; ageing; testosterone; randomized controlled trial |
Rights: | © Serdi and Springer-Verlag France 2016 |
DOI: | 10.1007/s12603-016-0689-y |
Grant ID: | http://purl.org/au-research/grants/nhmrc/627178 |
Published version: | http://dx.doi.org/10.1007/s12603-016-0689-y |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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