Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/103108
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dc.contributor.authorThakkar, V.-
dc.contributor.authorStevens, W.-
dc.contributor.authorPrior, D.-
dc.contributor.authorRabusa, C.-
dc.contributor.authorSahhar, J.-
dc.contributor.authorG Walker, J.-
dc.contributor.authorRoddy, J.-
dc.contributor.authorLester, S.-
dc.contributor.authorRischmueller, M.-
dc.contributor.authorZochling, J.-
dc.contributor.authorNash, P.-
dc.contributor.authorGabbay, E.-
dc.contributor.authorYoussef, P.-
dc.contributor.authorProudman, S.M.-
dc.contributor.authorNikpour, M.-
dc.date.issued2016-
dc.identifier.citationClinical and Experimental Rheumatology, 2016; 34(5 (Suppl.100)):129-136-
dc.identifier.issn0392-856X-
dc.identifier.issn1593-098X-
dc.identifier.urihttp://hdl.handle.net/2440/103108-
dc.descriptionPublished: 13/10/2016. CER8524-
dc.description.abstractOBJECTIVES: Asymmetric dimethylarginine (ADMA) is a novel biomarker of endothelial cell dysfunction. In this proof of concept study, we sought to evaluate the role of ADMA as a screening biomarker for incident systemic sclerosis-related pulmonary arterial hypertension (SSc-PAH). METHODS: ADMA levels were measured using high performance liquid chromatography in 15 consecutive treatment-naive patients with newly-diagnosed SSc-PAH and compared with 30 SSc-controls without PAH. Logistic regression models were used to evaluate the independent association of ADMA with PAH. The optimal cut-point of ADMA for SSc-PAH screening was determined. NT-proBNP levels were previously measured in the same patients and the optimal cut-point of NT-proBNP of ≥210ng/mL was coupled with the optimal cut-point of ADMA to create a screening model that combined the two biomarkers. RESULTS: The PAH group had significantly higher mean ADMA levels than the control group (0.76±0.14 μM versus 0.59±0.07 μM; p<0.0001). ADMA levels remained significantly associated with PAH after the adjustment for specific disease characteristics, cardiovascular risk factors and other SSc-related vascular complications (all p<0.01). An ADMA level ≥0.7 μM had a sensitivity of 86.7%, specificity of 90.0% and AUC of 0.86 for diagnosing PAH. A screening model that combined an NT-proBNP ≥210ng/mL and/ or ADMA ≥0.7 ng/mL resulted in a sensitivity of 100% and specificity of 90% for the detection of SSc-PAH. CONCLUSIONS: In this small study, use of ADMA in combination with NT-proBNP produced excellent sensitivity and specificity for the non-invasive identification of SSc-PAH. The role of ADMA as a screening biomarker for SSc-PAH merits further evaluation.-
dc.description.statementofresponsibilityV. Thakkar, W. Stevens, D. Prior, C. Rabusa, J. Sahhar, J. Walker, J. Roddy, S. Lester, M. Rischmueller, J. Zochling, P. Nash, E. Gabbay, P. Youssef, S. Proudman, M. Nikpour-
dc.language.isoen-
dc.publisherPacini editore-
dc.rightsCopyright status unknown-
dc.source.urihttp://www.clinexprheumatol.org/abstract.asp?a=9406-
dc.subjectPulmonary Artery-
dc.subjectHumans-
dc.subjectHypertension, Pulmonary-
dc.subjectScleroderma, Systemic-
dc.subjectNatriuretic Peptide, Brain-
dc.subjectArginine-
dc.subjectPeptide Fragments-
dc.subjectPrognosis-
dc.subjectChromatography, High Pressure Liquid-
dc.subjectArea Under Curve-
dc.subjectLogistic Models-
dc.subjectRisk Factors-
dc.subjectCase-Control Studies-
dc.subjectPredictive Value of Tests-
dc.subjectROC Curve-
dc.subjectAdult-
dc.subjectMiddle Aged-
dc.subjectAustralia-
dc.subjectFemale-
dc.subjectMale-
dc.subjectArterial Pressure-
dc.subjectBiomarkers-
dc.titleThe role of asymmetric dimethylarginine alone and in combination with N-terminal pro-B-type natriuretic peptide as a screening biomarker for systemic sclerosis-related pulmonary arterial hypertension: a case control study-
dc.typeJournal article-
pubs.publication-statusPublished-
dc.identifier.orcidLester, S. [0000-0003-3013-2701]-
dc.identifier.orcidRischmueller, M. [0000-0001-5057-3286]-
dc.identifier.orcidProudman, S.M. [0000-0002-3046-9884]-
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