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https://hdl.handle.net/2440/103108
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DC Field | Value | Language |
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dc.contributor.author | Thakkar, V. | - |
dc.contributor.author | Stevens, W. | - |
dc.contributor.author | Prior, D. | - |
dc.contributor.author | Rabusa, C. | - |
dc.contributor.author | Sahhar, J. | - |
dc.contributor.author | G Walker, J. | - |
dc.contributor.author | Roddy, J. | - |
dc.contributor.author | Lester, S. | - |
dc.contributor.author | Rischmueller, M. | - |
dc.contributor.author | Zochling, J. | - |
dc.contributor.author | Nash, P. | - |
dc.contributor.author | Gabbay, E. | - |
dc.contributor.author | Youssef, P. | - |
dc.contributor.author | Proudman, S.M. | - |
dc.contributor.author | Nikpour, M. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Clinical and Experimental Rheumatology, 2016; 34(5 (Suppl.100)):129-136 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.issn | 1593-098X | - |
dc.identifier.uri | http://hdl.handle.net/2440/103108 | - |
dc.description | Published: 13/10/2016. CER8524 | - |
dc.description.abstract | OBJECTIVES: Asymmetric dimethylarginine (ADMA) is a novel biomarker of endothelial cell dysfunction. In this proof of concept study, we sought to evaluate the role of ADMA as a screening biomarker for incident systemic sclerosis-related pulmonary arterial hypertension (SSc-PAH). METHODS: ADMA levels were measured using high performance liquid chromatography in 15 consecutive treatment-naive patients with newly-diagnosed SSc-PAH and compared with 30 SSc-controls without PAH. Logistic regression models were used to evaluate the independent association of ADMA with PAH. The optimal cut-point of ADMA for SSc-PAH screening was determined. NT-proBNP levels were previously measured in the same patients and the optimal cut-point of NT-proBNP of ≥210ng/mL was coupled with the optimal cut-point of ADMA to create a screening model that combined the two biomarkers. RESULTS: The PAH group had significantly higher mean ADMA levels than the control group (0.76±0.14 μM versus 0.59±0.07 μM; p<0.0001). ADMA levels remained significantly associated with PAH after the adjustment for specific disease characteristics, cardiovascular risk factors and other SSc-related vascular complications (all p<0.01). An ADMA level ≥0.7 μM had a sensitivity of 86.7%, specificity of 90.0% and AUC of 0.86 for diagnosing PAH. A screening model that combined an NT-proBNP ≥210ng/mL and/ or ADMA ≥0.7 ng/mL resulted in a sensitivity of 100% and specificity of 90% for the detection of SSc-PAH. CONCLUSIONS: In this small study, use of ADMA in combination with NT-proBNP produced excellent sensitivity and specificity for the non-invasive identification of SSc-PAH. The role of ADMA as a screening biomarker for SSc-PAH merits further evaluation. | - |
dc.description.statementofresponsibility | V. Thakkar, W. Stevens, D. Prior, C. Rabusa, J. Sahhar, J. Walker, J. Roddy, S. Lester, M. Rischmueller, J. Zochling, P. Nash, E. Gabbay, P. Youssef, S. Proudman, M. Nikpour | - |
dc.language.iso | en | - |
dc.publisher | Pacini editore | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://www.clinexprheumatol.org/abstract.asp?a=9406 | - |
dc.subject | Pulmonary Artery | - |
dc.subject | Humans | - |
dc.subject | Hypertension, Pulmonary | - |
dc.subject | Scleroderma, Systemic | - |
dc.subject | Natriuretic Peptide, Brain | - |
dc.subject | Arginine | - |
dc.subject | Peptide Fragments | - |
dc.subject | Prognosis | - |
dc.subject | Chromatography, High Pressure Liquid | - |
dc.subject | Area Under Curve | - |
dc.subject | Logistic Models | - |
dc.subject | Risk Factors | - |
dc.subject | Case-Control Studies | - |
dc.subject | Predictive Value of Tests | - |
dc.subject | ROC Curve | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Arterial Pressure | - |
dc.subject | Biomarkers | - |
dc.title | The role of asymmetric dimethylarginine alone and in combination with N-terminal pro-B-type natriuretic peptide as a screening biomarker for systemic sclerosis-related pulmonary arterial hypertension: a case control study | - |
dc.type | Journal article | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lester, S. [0000-0003-3013-2701] | - |
dc.identifier.orcid | Rischmueller, M. [0000-0001-5057-3286] | - |
dc.identifier.orcid | Proudman, S.M. [0000-0002-3046-9884] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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