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https://hdl.handle.net/2440/103144
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Type: | Journal article |
Title: | Increased survival after gemfibrozil treatment of severe mouse influenza |
Author: | Budd, A. Alleva, L. Alsharifi, M. Koskinen, A. Smythe, V. Müllbacher, A. Wood, J. Clark, I. |
Citation: | Antimicrobial Agents and Chemotherapy, 2007; 51(8):2965-2968 |
Publisher: | American Society for Microbiology |
Issue Date: | 2007 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Alison Budd, Lisa Alleva, Mohammed Alsharifi, Aulikki Koskinen, Victoria Smythe, Arno Mu, llbacher, Jeff Wood, and Ian Clark |
Abstract: | Gemfibrozil, an agent that inhibits production of proinflammatory cytokines in addition to its clinically useful lipid-lowering activity, increased survival in BALB/c mice that were already ill from infection by influenza virus A/Japan/305/57 (H2N2). Gemfibrozil was administered intraperitoneally once daily from days 4 to 10 after intranasal exposure to the virus. Survival increased from 26% in vehicle-treated mice (n = 50) to 52% in mice given gemfibrozil at 60 mg/kg/day (n = 46) (P = 0.0026). If this principle translates to patients, a drug already approved for human use, albeit by a different route for another purpose, might be adapted relatively fast for use against influenza, conceivably including human infection with a derivative of the avian H5N1 strain. |
Keywords: | Anti-Inflammatory Agents Gemfibrozil Hypolipidemic Agents Inflammation Orthomyxoviridae Infections Treatment Outcome |
Rights: | Copyright © 2007, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/AAC.00219-07 |
Published version: | http://dx.doi.org/10.1128/aac.00219-07 |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
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