Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/103585
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dc.contributor.authorThazhath, S.en
dc.contributor.authorMarathe, C.en
dc.contributor.authorWu, T.en
dc.contributor.authorChang, J.en
dc.contributor.authorKhoo, J.en
dc.contributor.authorKuo, P.en
dc.contributor.authorChecklin, H.en
dc.contributor.authorBound, M.en
dc.contributor.authorRigda, R.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorJones, K.en
dc.contributor.authorRayner, C.en
dc.date.issued2017en
dc.identifier.citationDiabetes and Vascular Disease Research, 2017; 14(1):59-63en
dc.identifier.issn1479-1641en
dc.identifier.issn1752-8984en
dc.identifier.urihttp://hdl.handle.net/2440/103585-
dc.description.abstractAim: To evaluate the effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate during an intraduodenal glucose infusion in type 2 diabetes. Methods: Nine subjects with type 2 diabetes were randomised to receive intravenous exenatide or saline control in a crossover design. Glucose (3 kcal min−1) was infused via an intraduodenal manometry catheter for 60 min. Blood pressure, heart rate, and the frequency and amplitude of duodenal pressure waves were measured at regular intervals. Gastrointestinal symptoms were monitored using 100 mm visual analogue scales. Results: During intraduodenal glucose infusion (0–60 min), diastolic (p(0–60) = 0.03) and mean arterial (p(0–60) = 0.03) blood pressures and heart rate (p(0–60) = 0.06; p(0–120) = 0.03)) were higher with exenatide compared to placebo. The increase in the area under the curve for diastolic blood pressure and mean arterial blood pressure was related directly to the suppression of the duodenal motility index with exenatide compared to control (p = 0.007 and 0.04, respectively). Conclusion: In type 2 diabetes, intravenous exenatide increases mean arterial blood pressure and heart rate during an intraduodenal glucose infusion, supporting the need for further research with exenatide for its potential use in postprandial hypotension.en
dc.description.statementofresponsibilitySony S Thazhath, Chinmay S Marathe, Tongzhi Wu, Jessica Chang, Joan Khoo, Paul Kuo, Helen L Checklin, Michelle J Bound, Rachael S Rigda, Michael Horowitz, Karen L Jones, and Christopher K Rayneren
dc.language.isoenen
dc.publisherSage Publication Ltden
dc.rights© The Author(s) 2016en
dc.subjectGlucagon-like peptide-1 receptor agonist; exenatide; ‘gut–heart axis'; postprandial hypotensionen
dc.titleAcute effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate responses to intraduodenal glucose infusion in type 2 diabetesen
dc.typeJournal articleen
dc.identifier.rmid0030059550en
dc.identifier.doi10.1177/1479164116666761en
dc.identifier.pubid280446-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS11en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWu, T. [0000-0003-1656-9210]en
dc.identifier.orcidRigda, R. [0000-0002-8924-5359]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
Appears in Collections:Medicine publications

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