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Type: Journal article
Title: Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes
Author: Wu, T.
Xie, C.
Wu, H.
Jones, K.
Horowitz, M.
Rayner, C.
Citation: Diabetes, Obesity and Metabolism, 2017; 19(2):290-293
Publisher: Wiley
Issue Date: 2017
ISSN: 1462-8902
Statement of
Tongzhi Wu MD, Cong Xie, Hang, Karen L. Jones, Michael Horowitz, Christopher K. Rayner
Abstract: In rodents, metformin slows intestinal glucose absorption, potentially increasing exposure of the distal gut to glucose to enhance postprandial glucagon-like peptide-1 (GLP-1) secretion. We evaluated the effects of metformin on serum 3-O-methylglucose (3-OMG; a marker of glucose absorption) and plasma total GLP-1 concentrations during a standardized intraduodenal infusion of glucose and 3-OMG in patients with type 2 diabetes. A total of 12 patients, treated with metformin 850 mg twice daily or placebo for 7 days each in a double-blind, randomized, crossover design (14 days’ washout between treatments), were evaluated on days 5 or 8 of each treatment (6 subjects each). On each study day, 30 minutes after ingesting 850 mg metformin or placebo, patients received an infusion of glucose (60 g + 5 g 3-OMG, dissolved in water to 240 mL) via an intraduodenal catheter over the course of 120 minutes. Compared with placebo, metformin was associated with lower serum 3-OMG (P < .001) and higher plasma total GLP-1 (P = .003) concentrations. The increment in plasma GLP-1 after metformin vs placebo was related to the reduction in serum 3-OMG concentrations (P = .019). Accordingly, metformin inhibits small intestinal glucose absorption, which may contribute to augmented GLP-1 secretion in type 2 diabetes.
Keywords: 3-O-methylglucose; glucagon-like pepetide-1; intestinal glucose absorption; metformin
Rights: © 2016 John Wiley & Sons Ltd
RMID: 0030057211
DOI: 10.1111/dom.12812
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Appears in Collections:Medicine publications

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