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|Title:||Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control|
|Citation:||Biomarkers in Medicine, 2016; 10(11):1167-1179|
|Publisher:||Future Medicine Ltd.|
|Tongzhi Wu, Christopher K Rayner, Michael Horowitz|
|Abstract:||The GI tract is central to the regulation of postprandial glycemia, with the rate of gastric emptying and the secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, being key determinants. Gastric emptying exhibits a large interindividual variation; the latter not only accounts for differences in postprandial glycemia but also determines postprandial incretin profiles. Accordingly, the rate of gastric emptying may affect the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors. In contrast, glucagon-like peptide-1 receptor agonists lower postprandial glycemia predominantly by their action to slow gastric emptying. This review discusses the inter-relationship between gastric emptying and the incretin axis in the context of changes in blood glucose, with an emphasis on the relevant clinical implications.|
|Rights:||Copyright status unknown|
|Appears in Collections:||Medicine publications|
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