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https://hdl.handle.net/2440/104185
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dc.contributor.author | Wu, T. | - |
dc.contributor.author | Zhang, X. | - |
dc.contributor.author | Trahair, L. | - |
dc.contributor.author | Bound, M. | - |
dc.contributor.author | Little, T. | - |
dc.contributor.author | Deacon, C. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Rayner, C. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2016; 101(12):4769-4778 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | http://hdl.handle.net/2440/104185 | - |
dc.description.abstract | Context: The rate of gastric emptying is an important determinant of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion, and may influence the magnitude of glucose-lowering by dipeptidyl peptidase-4 (DPP-4) inhibitors. Objective: To evaluate the effects of the DPP-4 inhibitor, vildagliptin, during intraduodenal (ID) glucose infusion at two different rates within the physiological range of gastric emptying, in type 2 diabetes. Participants and Design: A total of 16 diet-controlled type 2 diabetic patients were studied on four separate days in double-blind, randomized, fashion. On each day, either 50mg vildagliptin or placebo was given 60min prior to a 120min ID glucose infusion at 2 or 4kcal/min (ID2 or ID4). Plasma glucose and hormones were measured frequently. Results: Plasma glucose, insulin, C-peptide, glucagon, total GIP, and total and intact GLP-1 concentrations were higher during ID4 than ID2 (P<0.01 for each). Compared with placebo, vildagliptin was associated with higher intact GLP-1, insulin and C-peptide, and lower glucose and total GIP and GLP-1 (P<0.01 for each), without affecting glucagon. There were significant interactions between the rate of ID glucose and vildagliptin treatment on plasma glucose, intact and total GLP-1, and GIP (P<0.05 for each), but not insulin, C-peptide or glucagon. The reduction in glucose and the increment in intact GLP-1 after vildagliptin vs. placebo were 3.3 and 3.8 fold greater respectively, during ID4 compared to ID2. Conclusions/Interpretation: These observations warrant further study to clarify whether type 2 diabetic patients with relatively more rapid gastric emptying have greater glucose-lowering during treatment with DPP-4 inhibitors. | - |
dc.description.statementofresponsibility | Tongzhi Wu, Xiang Zhang, Laurence G. Trahair, Michelle J. Bound, Tanya J. Little, Carolyn F. Deacon, Michael Horowitz, Karen L. Jones, and Christopher K. Rayner | - |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | - |
dc.rights | Copyright © 2016 by the Endocrine Society | - |
dc.source.uri | http://dx.doi.org/10.1210/jc.2016-2813 | - |
dc.subject | Duodenum | - |
dc.subject | Humans | - |
dc.subject | Diabetes Mellitus, Type 2 | - |
dc.subject | Adamantane | - |
dc.subject | Nitriles | - |
dc.subject | Pyrrolidines | - |
dc.subject | Blood Glucose | - |
dc.subject | Infusions, Parenteral | - |
dc.subject | Double-Blind Method | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Dipeptidyl-Peptidase IV Inhibitors | - |
dc.subject | Vildagliptin | - |
dc.subject | Outcome Assessment, Health Care | - |
dc.title | Small intestinal glucose delivery affects the lowering of blood glucose by acute vildagliptin in type 2 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/jc.2016-2813 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1066815 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627011 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wu, T. [0000-0003-1656-9210] | - |
dc.identifier.orcid | Bound, M. [0000-0003-0211-5832] | - |
dc.identifier.orcid | Little, T. [0000-0001-9814-1036] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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