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https://hdl.handle.net/2440/104390
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Type: | Journal article |
Title: | Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas |
Author: | Wu, G. Broniscer, A. McEachron, T. Lu, C. Paugh, B. Becksfort, J. Qu, C. Ding, L. Huether, R. Parker, M. Zhang, J. Gajjar, A. Dyer, M. Mullighan, C. Gilbertson, R. Mardis, E. Wilson, R. Downing, J. Ellison, D. Zhang, J. et al. |
Citation: | Nature Genetics, 2012; 44(3):251-253 |
Publisher: | Nature Publishing Group |
Issue Date: | 2012 |
ISSN: | 1061-4036 1546-1718 |
Statement of Responsibility: | Gang Wu, Alberto Broniscer, Troy A McEachron, Charles Lu, Barbara S Paugh, Jared Becksfort, Chunxu Qu, Li Ding, Robert Huether, Matthew Parker, Junyuan Zhang, Amar Gajjar, Michael A Dyer, Charles G Mullighan, Richard J Gilbertson, Elaine R Mardis, Richard K Wilson, James R Downing, David W Ellison, Jinghui Zhang and Suzanne J Baker |
Abstract: | To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration. |
Keywords: | Brain Stem Neoplasms |
Rights: | © 2012 Nature America, Inc. All rights reserved. |
DOI: | 10.1038/ng.1102 |
Published version: | http://dx.doi.org/10.1038/ng.1102 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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