Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/104427
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Foraging activity is reduced in a mouse model of depression |
Author: | Yang, C. Zhang, Z. Bai, Y. Zhou, H. Zhou, L. Ruan, C. Li, F. Li, C. Zheng, H. Shen, L. Zhou, X. |
Citation: | Neurotoxicity Research, 2014; 25(3):235-247 |
Publisher: | Springer |
Issue Date: | 2014 |
ISSN: | 1029-8428 1476-3524 |
Statement of Responsibility: | C.R. Yang, Z.G. Zhang, Y.Y. Bai, H. Fiona Zhou, L. Zhou, C.S. Ruan, F. Li, C.Q. Li, H.Y. Zheng, L.J. Shen, X.F. Zhou |
Abstract: | Depression interferes with the human ability to make decisions. Multiple criteria have been adopted for the diagnosis of depression in humans, but no clear indicators are available in animal models to reflect the depressive mood, involving higher cognitive functions. The act of foraging is a species-specific behaviour which is believed to involve the decision-making and higher cognitive functions. We previously established a method to detect the foraging behaviour of rodents, in which our results demonstrated that NMDA and dopamine receptors were involved. Conversely, increased NMDA receptors and reduced dopamine have been reported in depression model rodents. However, we hypothesise that foraging activities may also be impaired in depression. To test the theory, we successfully established a mouse model of depression using the chronic unpredictable mild stress (CUMS) paradigm. Most interestingly, the food foraging activity of mice after CUMS was significantly reduced. In addition, the treatment of anti-depressant fluoxetine reversed most depressive symptoms and reduced glial fibrillary associated protein (GFAP) expression in the hippocampus, but was less effective in the reduction of foraging activities. However, clozapine reversed all symptoms of CUMS-exposed mice including reduction of GFAP expression in the hippocampus and impaired foraging activity. Our findings of GFAP expression as a marker to validate the CUMS protocol provide further validation of our hypothesis, that the reduced food foraging is probably a new behavioural finding of depression in which the serotoninergic system could not be singly involved. Our study suggests that NMDA receptors, serotoninergic and dopaminergic systems are differentially involved in these food foraging behaviours. Our data suggest that the foraging test in rodents can be a useful tool to assess the ability of decision-making in depression. |
Keywords: | Foraging activity; depression; decision-making; anti-depressant; GFAP |
Rights: | © Springer Science+Business Media New York 2013 |
DOI: | 10.1007/s12640-013-9411-6 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/595937 |
Published version: | http://dx.doi.org/10.1007/s12640-013-9411-6 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.