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Type: Journal article
Title: Genome-wide search for markers associated with bovine spongiform encephalopathy
Author: Hernández-Sánchez, J.
Waddington, D.
Wiener, P.
Haley, C.
Williams, J.
Citation: Mammalian Genome, 2002; 13(3):164-168
Publisher: Springer-Verlag
Issue Date: 2002
ISSN: 0938-8990
Statement of
Jules Hernández-Sánchez, Dave Waddington, Pamela Wiener, Chris S. Haley, John L. Williams
Abstract: A genome-wide search for markers associated with BSE incidence was performed by using Transmission-Disequilibrium Tests (TDTs). Significant segregation distortion, i.e., unequal transmission probabilities of alleles within a locus, was found for three marker loci on Chromosomes (Chrs) 5, 10, and 20. Although TDTs are robust to false associations owing to hidden population substructures, it cannot distinguish segregation distortion caused by a true association between a marker and bovine spongiform encephalopathy (BSE) from a population-wide distortion. An interaction test and a segregation distortion analysis in half-sib controls were used to disentangle these two alternative hypotheses. None of the markers showed any significant interaction between allele transmission rates and disease status, and only the marker on Chr 10 showed a significant segregation distortion in control individuals. Nevertheless, the control group may have been a mixture of resistant and susceptible but unchallenged individuals. When new genotypes were generated in the vicinity of these three markers, evidence for an association with BSE was confirmed for the locus on Chr 5.
Keywords: Chromosome Mapping; Encephalopathy, Bovine Spongiform; Genetic Predisposition to Disease
Rights: © Springer-Verlag New York Inc. 2002
RMID: 0030068335
DOI: 10.1007/BF02684022
Appears in Collections:Animal and Veterinary Sciences publications

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