Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/104666
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Type: Journal article
Title: XThe eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation
Author: Leprivier, G.
Remke, M.
Rotblat, B.
Dubuc, A.
Mateo, A.
Kool, M.
Agnihotri, S.
El-Naggar, A.
Yu, B.
Prakash Somasekharan, S.
Faubert, B.
Bridon, G.
Tognon, C.
Mathers, J.
Thomas, R.
Li, A.
Barokas, A.
Kwok, B.
Bowden, M.
Smith, S.
et al.
Citation: Cell, 2013; 153(5):1064-1079
Publisher: Cell Press
Issue Date: 2013
ISSN: 0092-8674
1097-4172
Statement of
Responsibility: 
Gabriel Leprivier, Marc Remke, Barak Rotblat, Adrian Dubuc, Abigail-Rachele F. Mateo … Proud, Christopher G (Chris) …et al.
Abstract: Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation. Tumor cells exploit this pathway to adapt to nutrient deprivation by reactivating the AMPK-eEF2K axis. Adaptation of transformed cells to nutrient withdrawal is severely compromised in cells lacking eEF2K. Moreover, eEF2K knockdown restored sensitivity to acute nutrient deprivation in highly resistant human tumor cell lines. In vivo, overexpression of eEF2K rendered murine tumors remarkably resistant to caloric restriction. Expression of eEF2K strongly correlated with overall survival in human medulloblastoma and glioblastoma multiforme. Finally, C. elegans strains deficient in efk-1, the eEF2K ortholog, were severely compromised in their response to nutrient depletion. Our data highlight a conserved role for eEF2K in protecting cells from nutrient deprivation and in conferring tumor cell adaptation to metabolic stress. PAPERCLIP:
Keywords: Neoplasms
Rights: ©2013 Elsevier Inc. All rights reserved.
RMID: 0030035740
DOI: 10.1016/j.cell.2013.04.055
Appears in Collections:Molecular and Biomedical Science publications

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