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Type: Journal article
Title: Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
Author: Lane, J.
Liang, J.
Vlasac, I.
Anderson, S.
Bechtold, D.
Bowden, J.
Emsley, R.
Gill, S.
Little, M.
Luik, A.
Loudon, A.
Scheer, F.
Purcell, S.
Kyle, S.
Lawlor, D.
Zhu, X.
Redline, S.
Ray, D.
Rutter, M.
Saxena, R.
Citation: Nature Genetics, 2017; 49(2):274-281
Issue Date: 2017
ISSN: 1061-4036
Statement of
Jacqueline M Lane, Jingjing Liang, Irma Vlasac, Simon G Anderson, David A Bechtold, Jack Bowden, Richard Emsley, Shubhroz Gill, Max A Little, Annemarie I Luik, Andrew Loudon, Frank A J L Scheer, Shaun M Purcell, Simon D Kyle, Deborah A Lawlor, Xiaofeng Zhu, Susan Redline, David W Ray, Martin K Rutter, Richa Saxena
Abstract: Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders and all-cause mortality¹’², affect 25–30% of adults worldwide³. Although environmental factors contribute substantially to self-reported habitual sleep duration and disruption, these traits are heritable⁴¯⁹ and identification of the genes involved should improve understanding of sleep, mechanisms linking sleep to disease and development of new therapies. We report single- and multiple-trait genome-wide association analyses of self-reported sleep duration, insomnia symptoms and excessive daytime sleepiness in the UK Biobank (n = 112,586). We discover loci associated with insomnia symptoms (near MEIS1, TMEM132E, CYCL1 and TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR–OPHN1) and a composite sleep trait (near PATJ (INADL) and HCRTR2) and replicate a locus associated with sleep duration (at PAX8). We also observe genetic correlation between longer sleep duration and schizophrenia risk (rg = 0.29, P = 1.90 × 10−¹³) and between increased levels of excessive daytime sleepiness and increased measures for adiposity traits (body mass index (BMI): rg = 0.20, P = 3.12 × 10⁻⁹; waist circumference: rg = 0.20, P = 2.12 × 10⁻⁷).
Keywords: Behavioural genetics; genome-wide association studies
Rights: © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.
RMID: 0030060955
DOI: 10.1038/ng.3749
Appears in Collections:Medicine publications

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