Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105155
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dc.contributor.authorChang, S.en
dc.contributor.authorWen, C.en
dc.contributor.authorTsai, M.en
dc.contributor.authorLawlor, D.en
dc.contributor.authorYang, Y.en
dc.contributor.authorGunnell, D.en
dc.date.issued2012en
dc.identifier.citationAmerican Journal of Epidemiology, 2012; 175(8):804-815en
dc.identifier.issn0002-9262en
dc.identifier.issn1476-6256en
dc.identifier.urihttp://hdl.handle.net/2440/105155-
dc.description.abstractRecent studies in Western nations have shown inverse associations between body mass index (BMI, measured as weight (kg)/height (m)2) and suicide. However, it is uncertain whether the association is similar in non-Western settings, and the biologic pathways underlying the association are unclear. The authors investigated these issues in a cohort of 542,088 Taiwanese people 20 years of age or older who participated in a health check-up program (1994–2008); there were 573 suicides over a mean 8.1 years of follow up. There was a J-shaped association between BMI and suicide risk (P for the quadratic term = 0.033) but limited evidence of a linear association (adjusted hazard ratio per 1-standard-deviation increase = 0.95 (95% confidence interval: 0.85, 1.06)); compared with individuals whose BMI was 18.5–22.9, adjusted hazard ratios for those with a BMI <18.5 or ≥35 were 1.56 (95% confidence interval: 1.07, 2.28) and 3.62 (95% confidence interval: 1.59, 8.22), respectively. A high waist-to-hip ratio was associated with an increased risk of suicide. There was some evidence for a reverse J-shaped association of systolic blood pressure and high density lipoprotein cholesterol with suicide and an association of higher triglyceride level with increased suicide risk; these associations did not appear to mediate the associations of BMI and waist-to-hip ratio with suicide.en
dc.description.statementofresponsibilityShu-Sen Chang, Chi Pang Wen, Min Kuang Tsai, Debbie A. Lawlor, Yi Chen Yang, and David Gunnellen
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© The Author 2012. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.en
dc.subjectbody mass index; cholesterol; cohort studies; suicide; systolic blood pressure; Taiwan; triglycerides; waist-to-hip ratioen
dc.titleAdiposity, its related biologic risk factors, and suicide: a cohort study of 542,088 Taiwanese adultsen
dc.typeJournal articleen
dc.identifier.rmid0030042870en
dc.identifier.doi10.1093/aje/kwr386en
dc.identifier.pubid232899-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS11en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLawlor, D. [0000-0002-6793-2262]en
Appears in Collections:Medicine publications

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