Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105628
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dc.contributor.authorAdams, R.en
dc.contributor.authorAppleton, S.en
dc.contributor.authorVakulin, A.en
dc.contributor.authorHanly, P.en
dc.contributor.authorMcDonald, S.en
dc.contributor.authorMartin, S.en
dc.contributor.authorLang, C.en
dc.contributor.authorTaylor, A.en
dc.contributor.authorMcEvoy, R.en
dc.contributor.authorAntic, N.en
dc.contributor.authorCatchside, P.en
dc.contributor.authorVincent, A.en
dc.contributor.authorWittert, G.en
dc.date.issued2017en
dc.identifier.citationSleep, 2017; 40(1):zsw015-1-zsw015-9en
dc.identifier.issn0161-8105en
dc.identifier.issn1550-9109en
dc.identifier.urihttp://hdl.handle.net/2440/105628-
dc.description.abstractStudy Objectives: To determine the relationship between obstructive sleep apnea (OSA) and chronic kidney disease (CKD). Previous population studies of the association are sparse, conflicting and confined largely to studies of administrative data. Methods: Cross-sectional analysis in unselected participants of the Men Androgens Inflammation Lifestyle Environment and Stress (MAILES) study, aged >40 years. Renal data were available for 812 men without a prior OSA diagnosis who underwent full in-home polysomnography (Embletta X100) in 2010–2011. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2 or eGFR≥60 and albuminuria (albumin–creatinine ratio ≥3.0 mg/mmol). Results: CKD (10.5%, n = 85 [Stage 1–3, 9.7%; Stage 4–5, 0.7%]) of predominantly mild severity showed significant associations with OSA (apnea–hypoapnea index [AHI] ≥ 10): odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.02–3.5; severe OSA (AHI ≥ 30/h): OR = 2.6, 95% CI: 1.1–6.2; and respiratory-related arousal index: ≥7.6/h, OR = 2.3, 95%CI: 1.1–4.7; but not measures of hypoxemia after adjustment for age, hypertension, diabetes, smoking, obesity, and NSAID use. There was no association of CKD with daytime sleepiness. In men with CKD, those with OSA were not significantly more likely to report symptoms (sleepiness, snoring, and apneas) or be identified with the STOP OSA screening questionnaire, compared to men without OSA. Conclusions: Predominantly mild CKD is associated with severe OSA and arousals. Further population studies examining the longitudinal relationship between CKD and OSA are warranted. Better methods are needed to identify OSA in CKD which may have few symptoms.en
dc.description.statementofresponsibilityRobert J. Adams, Sarah L. Appleton, Andrew Vakulin, Patrick J. Hanly, Stephen P. McDonald, Sean A. Martin, Carol J. Lang, Anne W. Taylor, R. Doug McEvoy, Nick A. Antic, Peter G. Catcheside, Andrew D. Vincent, Gary A. Witterten
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.en
dc.subjectChronic kidney disease; epidemiology; obstructive sleep apnea; men; cohort studyen
dc.titleChronic kidney disease and sleep apnea association of kidney disease with obstructive sleep apnea in a population study of menen
dc.typeJournal articleen
dc.identifier.rmid0030066274en
dc.identifier.doi10.1093/sleep/zsw015en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627227en
dc.identifier.pubid292544-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidAppleton, S. [0000-0001-7292-9714]en
dc.identifier.orcidMcDonald, S. [0000-0001-6103-1386]en
dc.identifier.orcidLang, C. [0000-0002-3832-6984]en
dc.identifier.orcidTaylor, A. [0000-0002-4422-7974]en
dc.identifier.orcidMcEvoy, R. [0000-0002-5759-0094]en
dc.identifier.orcidVincent, A. [0000-0002-6428-1070]en
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]en
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