Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105797
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Type: | Journal article |
Title: | Intensity modulated radiation therapy dose painting for localized prostate cancer using¹¹C-choline positron emission tomography scans |
Other Titles: | Intensity modulated radiation therapy dose painting for localized prostate cancer using(11)C-choline positron emission tomography scans |
Author: | Chang, J. Lim Joon, D. Lee, S. Gong, S. Anderson, N. Scott, A. Davis, I. Clouston, D. Bolton, D. Hamilton, C. Khoo, V. |
Citation: | International Journal of Radiation: Oncology - Biology - Physics, 2012; 83(5):e691-e696 |
Publisher: | Elsevier |
Issue Date: | 2012 |
ISSN: | 0360-3016 1879-355X |
Statement of Responsibility: | Joe H. Chang, Daryl Lim Joon, Sze Ting Lee, Sylvia J. Gong, Nigel J. Anderson, Andrew M. Scott, Ian D. Davis, David Clouston, Damien Bolton, Christopher S. Hamilton, Vincent Khoo |
Abstract: | PURPOSE: To demonstrate the technical feasibility of intensity modulated radiation therapy (IMRT) dose painting using¹¹C-choline positron emission tomography PET scans in patients with localized prostate cancer. METHODS AND MATERIALS: This was an RT planning study of 8 patients with prostate cancer who had ¹¹C-choline PET scans prior to radical prostatectomy. Two contours were semiautomatically generated on the basis of the PET scans for each patient: 60% and 70% of the maximum standardized uptake values (SUV(60%) and SUV(70%)). Three IMRT plans were generated for each patient: PLAN(78), which consisted of whole-prostate radiation therapy to 78 Gy; PLAN(78-90), which consisted of whole-prostate RT to 78 Gy, a boost to the SUV(60%) to 84 Gy, and a further boost to the SUV(70%) to 90 Gy; and PLAN(72-90), which consisted of whole-prostate RT to 72 Gy, a boost to the SUV(60%) to 84 Gy, and a further boost to the SUV(70%) to 90 Gy. The feasibility of these plans was judged by their ability to reach prescription doses while adhering to published dose constraints. Tumor control probabilities based on PET scan-defined volumes (TCP(PET)) and on prostatectomy-defined volumes (TCP(path)), and rectal normal tissue complication probabilities (NTCP) were compared between the plans. RESULTS: All plans for all patients reached prescription doses while adhering to dose constraints. TCP(PET) values for PLAN(78), PLAN(78-90), and PLAN(72-90) were 65%, 97%, and 96%, respectively. TCP(path) values were 71%, 97%, and 89%, respectively. Both PLAN(78-90) and PLAN(72-90) had significantly higher TCP(PET) (P=.002 and .001) and TCP(path) (P<.001 and .014) values than PLAN(78). PLAN(78-90) and PLAN(72-90) were not significantly different in terms of TCP(PET) or TCP(path). There were no significant differences in rectal NTCPs between the 3 plans. CONCLUSIONS: IMRT dose painting for localized prostate cancer using (11)C-choline PET scans is technically feasible. Dose painting results in higher TCPs without higher NTCPs. |
Keywords: | Dose painting; C-choline, Positron emission tomography; prostrate cancer; IMRT |
Rights: | Copyright © 2012 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.ijrobp.2012.01.087 |
Published version: | http://dx.doi.org/10.1016/j.ijrobp.2012.01.087 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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File | Description | Size | Format | |
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hdl_105797.pdf | Accepted version | 324.87 kB | Adobe PDF | View/Open |
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