Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106259
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Type: Journal article
Title: Non-invasive volumetric assessment of aortic atheroma: a core laboratory validation using computed tomography angiography
Author: Hammadah, M.
Qintar, M.
Nissen, S.
John, J.
Alkharabsheh, S.
Mobolaji-Lawal, M.
Philip, F.
Uno, K.
Kataoka, Y.
Babb, B.
Poliszczuk, R.
Kapadia, S.
Tuzcu, E.
Schoenhagen, P.
Nicholls, S.
Puri, R.
Citation: International Journal of Cardiovascular Imaging, 2016; 32(1):121-129
Publisher: Springer
Issue Date: 2016
ISSN: 1569-5794
1573-0743
Statement of
Responsibility: 
Muhammad Hammadah, Mohammed Qintar, Steven E. Nissen, Julie St. John, Saqer Alkharabsheh, Motunrayo Mobolaji-Lawal, Femi Philip, Kiyoko Uno, Yu Kataoka, Brett Babb, Roman Poliszczuk, Samir R. Kapadia, E. Murat Tuzcu, Paul Schoenhagen, Stephen J. Nicholls, Rishi Puri
Abstract: Aortic atherosclerosis has been linked with worse peri- and post-procedural outcomes following a range of aortic procedures. Yet, there are currently no standardized methods for non-invasive volumetric pan-aortic plaque assessment. We propose a novel means of more accurately assessing plaque volume across whole aortic segments using computed tomography angiography (CTA) imaging. Sixty patients who underwent CTA prior to trans-catheter aortic valve implantation were included in this analysis. Specialized software analysis (3mensio Vascular™, Pie Medical, Maastricht, Netherlands) was used to reconstruct images using a centerline approach, thus creating true cross-sectional aortic images, akin to those images produced with intravascular ultrasonography. Following aortic segmentation (from the aortic valve to the renal artery origin), atheroma areas were measured across multiple contiguous evenly spaced (10 mm) cross-sections. Percent atheroma volume (PAV), total atheroma volume (TAV) and calcium score were calculated. In our populations (age 79.9 ± 8.5 years, male 52 %, diabetes 27 %, CAD 84 %, PVD 20 %), mean ± SD number of cross sections measured for each patient was 35.1 ± 3.5 sections. Mean aortic PAV and TAV were 33.2 ± 2.51 % and 83,509 ± 17,078 mm(3), respectively. Median (IQR) calcium score was 1.5 (0.7-2.5). Mean (SD) inter-observer coefficient of variation and agreement for plaque area among 4 different analysts was 14.1 (5.4), and the mean (95 % CI) Lin's concordance correlation coefficient was 0.79 (0.62-0.89), effectively simulating a Core Laboratory scenario. We provide an initial validation of cross-sectional volumetric aortic atheroma assessment using CTA. This proposed methodology highlights the potential for utilizing non-invasive aortic plaque imaging for risk prediction across a range of clinical scenarios.
Keywords: Aortic atheroma; plaque volume; CTA; CT angiogram
Rights: © Springer Science+Business Media Dordrecht 2015
RMID: 0030031487
DOI: 10.1007/s10554-015-0674-2
Appears in Collections:Medicine publications

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