Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106324
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Adipose and height growth through childhood and blood pressure status in a large prospective cohort study
Author: Jones, A.
Charakida, M.
Falaschetti, E.
Hingorani, A.
Finer, N.
Masi, S.
Donald, A.
Lawlor, D.
Smith, G.
Deanfield, J.
Citation: Hypertension, 2012; 59(5):919-925
Publisher: Lippincott Williams & Wilkins
Issue Date: 2012
ISSN: 0194-911X
1524-4563
Statement of
Responsibility: 
Alexander Jones, Marietta Charakida, Emanuela Falaschetti, Aroon D. Hingorani, Nicholas Finer, Stefano Masi, Ann E. Donald, Debbie A. Lawlor, George Davey Smith, John E. Deanfield
Abstract: Raised blood pressure (BP) is the world's leading mortality risk factor. Childhood BP substantially predicts adult levels, and although both prenatal and postnatal growth influence it, their relative importance is debated. In a longitudinal study (Avon Longitudinal Study of Parents and Children) of 12 962 healthy children, we aimed to assess the relative contribution of different growth periods and of standardized measures of height versus weight-for-height (an adiposity marker) to BP at age 10 years. Conditional growth modeling was used in the 3230 boys and 3346 girls with BP measurements. Systolic BP was inversely associated with birth weight and weight-for-height but not length (-0.33, -0.27, and -0.12 mm Hg · SD(-1); P=0.003, 0.035, and 0.35, respectively). In infancy, weight, weight-for-height, and height gains were all positively associated with systolic BP (0.90, 0.41, and 0.82 mm Hg · SD(-1), respectively; all P<0.001). After infancy, all of the growth modalities were positively associated with systolic BP (weight, 1.91; weight-for-height, 1.56; height, 1.20 mm Hg · SD(-1); all P<0.001). Similar but weaker associations were found with diastolic BP. Although BP at 10 years was associated with both prenatal and early postnatal growth, their influence was small compared with that of later growth. Because BP ranking relative to the population is substantially determined in the first decade of life, a focus on strategies to reduce the development of adiposity from infancy onward, rather than an emphasis on the nutrition and weight of mothers and infants, should bring greater reductions in population BP.
Keywords: blood pressure; childhood growth; hypertension; obesity; population
Rights: © 2012 American Heart Association, Inc.
RMID: 0030042843
DOI: 10.1161/HYPERTENSIONAHA.111.187716
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.