Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106519
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Type: Journal article
Title: Comparative effects of glucose and water drinks on blood pressure and cardiac function in older subjects with and without postprandial hypotension
Author: Trahair, L.
Rajendran, S.
Visvanathan, R.
Chapman, M.
Stadler, D.
Horowitz, M.
Jones, K.
Citation: Physiological Reports, 2017; 5(13):e13341-1-e13341-11
Publisher: Wiley
Issue Date: 2017
ISSN: 2051-817X
2051-817X
Statement of
Responsibility: 
Laurence G. Trahair, Sharmalar Rajendran, Renuka Visvanathan, Matthew Chapman, Daniel Stadler, Michael Horowitz and Karen L. Jones
Abstract: Postprandial hypotension (PPH) occurs frequently and is thought to reflect an inadequate increase in cardiac output to compensate for the rise in splanchnic blood flow after a meal. Gastric distension by water attenuates the postprandial fall in blood pressure (BP). Cardiac hemodynamics (stroke volume (SV), cardiac output (CO), and global longitudinal strain (GLS)) have hitherto not been measured in PPH We sought to determine the comparative effects of water and glucose drinks on cardiac hemodynamics in healthy older subjects and individuals with PPH Eight healthy older subjects (age 71.0 ± 1.7 years) and eight subjects with PPH (age 75.5 ± 1.0 years) consumed a 300 mL drink of either water or 75 g glucose (including 150 mg 13C-acetate) in randomized order. BP and heart rate (HR) were measured using an automatic device, SV, CO, and GLS by transthoracic echocardiography and gastric emptying by measurement of 13CO2 In both groups, glucose decreased systolic BP (P < 0.001) and increased HR, SV, and CO (P < 0.05 for all). The fall in systolic BP was greater (P < 0.05), and increase in HR less (P < 0.05), in the PPH group, with no difference in SV or CO Water increased systolic BP (P < 0.05) in subjects with PPH and, in both groups, decreased HR (P < 0.05) without affecting SV, CO, or GLS In subjects with PPH, the hypotensive response to glucose and the pressor response to water were related (R = -0.75, P < 0.05). These observations indicate that, in PPH, the hypotensive response to oral glucose is associated with inadequate compensatory increases in CO and HR, whereas the pressor response to water ingestion is maintained and, possibly, exaggerated.
Keywords: Autonomic function; baroreflex; blood pressure; echocardiography; glucose; hypotension
Rights: © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
RMID: 0030072842
DOI: 10.14814/phy2.13341
Grant ID: http://purl.org/au-research/grants/nhmrc/627189
Appears in Collections:Medicine publications

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