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https://hdl.handle.net/2440/106618
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dc.contributor.author | Chowdhury, M. | - |
dc.contributor.author | McKenzie, S. | - |
dc.contributor.author | Pearson, C. | - |
dc.contributor.author | Carr, S. | - |
dc.contributor.author | Pao, C. | - |
dc.contributor.author | Shah, A. | - |
dc.contributor.author | Reus, E. | - |
dc.contributor.author | Eliahoo, J. | - |
dc.contributor.author | Gordon, F. | - |
dc.contributor.author | Bland, H. | - |
dc.contributor.author | Habibi, P. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Pediatrics, 2013; 131(4):661-669 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.issn | 1098-4275 | - |
dc.identifier.uri | http://hdl.handle.net/2440/106618 | - |
dc.description.abstract | Background and Objective: Supportive care remains the mainstay of therapy in bronchiolitis. Earlier studies suggest that helium-oxygen therapy may be beneficial, but evidence is limited. We aimed to compare efficacy of 2 treatment gases, Heliox and Airox (21% oxygen + 79% helium or nitrogen, respectively), on length of hospital treatment for bronchiolitis. Methods: This was a multicenter randomized blinded controlled trial of 319 bronchiolitic infant subjects randomly assigned to either gas; 281 subjects completed the study (140 Heliox, 141 Airox), whose data was analyzed. Treatment was delivered via facemask (nasal cannula, if the facemask intolerant) ± continuous positive airway pressure (CPAP). Severe bronchiolitics received CPAP from the start. Primary end point was length of treatment (LoT) required to alleviate hypoxia and respiratory distress. Secondary end-points were proportion of subjects needing CPAP; CPAP (LoT); and change in respiratory distress score. Results: Analysis by intention to treat (all subjects); median LoT (inter-quartile range, days): Heliox 1.90 (1.08-3.17), Airox 1.87 (1.11-3.34), P = .41. Facemask tolerant subgroup: Heliox 1.46 (0.85-1.95), Airox 2.01 (0.93-2.86), P = .03. Nasal cannula subgroup: Heliox 2.51 (1.21-4.32), Airox 2.81 (1.45-4.78), P = .53. Subgroup started on CPAP: Heliox 1.55 (1.38-2.01), Airox 2.26 (1.84-2.73), P = .02. Proportion of subjects needing CPAP: Heliox 17%, Airox 19%, O.R. 0.87 (0.47-1.60), P = .76. Heliox reduced respiratory distress score after 8 hours (mixed models estimate, -0.1298; P < .001). The effect was greater for facemask compared with nasal cannula (mixed models estimate, 0.093; P = .04). Conclusions: Heliox therapy does not reduce LoT unless given via a tight-fitting facemask or CPAP. Nasal cannula heliox therapy is ineffective. | - |
dc.description.statementofresponsibility | Mina M. Chowdhury, Sheila A. McKenzie, Christopher C. Pearson, Siobhan Carr, Caroline Pao, Arvind R. Shah, Elizabeth Reus, Joseph Eliahoo, Fabiana Gordon, Hubert Bland and Parviz Habibi | - |
dc.language.iso | en | - |
dc.publisher | American Academy of Pediatrics | - |
dc.rights | Copyright © 2013 by the American Academy of Pediatrics. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1542/peds.2012-1317 | - |
dc.subject | Randomized controlled trial; heliox; bronchiolitis | - |
dc.title | Heliox therapy in bronchiolitis: phase III multicenter double-blind randomized controlled trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1542/peds.2012-1317 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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