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Type: Journal article
Title: In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts
Author: Ling, K.
Brautigan, P.
Moore, S.
Fraser, R.
Leong, M.
Leong, J.
Zainal Abidin, S.
Lee, H.
Cheah, P.
Raison, J.
Babic, M.
Lee, Y.
Daish, T.
Mattiske, D.
Mann, J.
Adelson, D.
Thomas, P.
Hahn, C.
Scott, H.
Citation: Data in Brief, 2016; 7:282-290
Publisher: Elsevier
Issue Date: 2016
ISSN: 2352-3409
Statement of
King-Hwa Ling, Peter J. Brautigan, Sarah Moore, Rachel Fraser, Melody Pui-Yee Leong, Jia-Wen Leong, Shahidee Zainal Abidin, Han-Chung Lee, Pike-See Cheah, Joy M. Raison, Milena Babic, Young Kyung Lee, Tasman Daish, Deidre M. Mattiske, Jeffrey R. Mann, David L. Adelson, Paul Q. Thomas, Christopher N. Hahn, Hamish S.Scott
Abstract: SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1], [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.
Keywords: Endogenous siRNA; Brain development; Natural antisense transcripts
Description: Available online 17 February 2016
Rights: © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (
RMID: 0030044935
DOI: 10.1016/j.dib.2016.01.045
Grant ID:
Appears in Collections:Molecular and Biomedical Science publications

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