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https://hdl.handle.net/2440/107111
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dc.contributor.author | Patel, S. | - |
dc.contributor.author | Lawlor, D. | - |
dc.contributor.author | Callaway, M. | - |
dc.contributor.author | Macdonald-Wallis, C. | - |
dc.contributor.author | Sattar, N. | - |
dc.contributor.author | Fraser, A. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | BMC Pediatrics, 2016; 16(1):47-1-47-13 | - |
dc.identifier.issn | 1471-2431 | - |
dc.identifier.issn | 1471-2431 | - |
dc.identifier.uri | http://hdl.handle.net/2440/107111 | - |
dc.description.abstract | Background: Little is known about early life determinants of non-alcoholic fatty liver disease (NAFLD). We examined associations of maternal pregnancy diabetes/glycosuria and pre-pregnancy body mass index (BMI) with offspring markers of NAFLD and liver pathology and examined mediation by birthweight and concurrent offspring adiposity. Methods: We used data from a UK prospective pregnancy cohort. Offspring underwent abdominal ultrasonography (USS) at mean age 17.8 years. Outcomes included USS-assessed fatty liver, estimated liver volume and shear velocity, a variant of elastography (a marker of liver fibrosis) (N = 1 215) and blood-based markers of liver pathology [alanine amino transferase, aspartate amino transferase, gamma- glutamyltransferase and haptoglobin] (N = 2 359). Results: 2.1 % (N = 25) of participants had USS-assessed fatty liver [maternal diabetes/glycosuria (N = 7) and no diabetes/glycosuria (N = 18)]. Maternal diabetes/glycosuria was associated with greater odds of offspring USS fatty liver in confounder adjusted models [adjusted odds ratio (aOR) 6.74 (95 % confidence interval (CI) 2.47, 18.40)] and higher shear velocity [adjusted ratio of geometric mean (aRGM):1.10 (95 % CI 1.05, 1.15)]. These associations were not mediated by offspring birthweight or concurrent adiposity. Maternal diabetes/glycosuria was not associated with liver volume or blood-based outcomes. Greater maternal pre-pregnancy BMI was associated with greater odds of offspring USS fatty liver [aOR 2.72 (95 % CI: 1.20, 6.15)], higher liver volume [aRGM 1.03 (95 % CI 1.00, 1.07)] and shear velocity [aRGM1.03 (95 % CI: 1.01, 1.06)] in confounder adjusted models. These associations were largely mediated by offspring adiposity. Maternal pre-pregnancy BMI was not consistently associated with blood-based outcomes. Conclusions: Results suggest that maternal pregnancy diabetes/glycosuria is associated with offspring NAFLD through mechanisms other than offspring’s own adiposity. | - |
dc.description.statementofresponsibility | Sumaiya Patel, Debbie A. Lawlor, Mark Callaway, Corrie Macdonald-Wallis, Naveed Sattar and Abigail Fraser | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central | - |
dc.rights | © Patel et al. 2016 | - |
dc.source.uri | http://dx.doi.org/10.1186/s12887-016-0585-y | - |
dc.subject | Pregnancy diabetes; glycosuria; obesity; NAFLD; fetal overnutrition; ALSPAC | - |
dc.title | Association of maternal diabetes/glycosuria and pre-pregnancy body mass index with offspring indicators of non-alcoholic fatty liver disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/s12887-016-0585-y | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lawlor, D. [0000-0002-6793-2262] | - |
Appears in Collections: | Aurora harvest 8 Paediatrics publications |
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