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https://hdl.handle.net/2440/108
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Type: | Journal article |
Title: | Synthesis of complex oligosaccharides by using a mutated (1,3)-beta-D-glucan endohydrolase from barley |
Author: | Fairweather, J. Hrmova, M. Rutten, S. Fincher, G. Driguez, H. |
Citation: | Chemistry: A European Journal, 2003; 9(11):2603-2610 |
Publisher: | Wiley-V C H Verlag GMBH |
Issue Date: | 2003 |
ISSN: | 0947-6539 1521-3765 |
Statement of Responsibility: | Jon K. Fairweather, Maria Hrmova, Simon J. Rutten, Geoffrey B. Fincher, Hugues Driguez |
Abstract: | Complex oligosaccharides with newly formed (1,3)-β-glycosidic linkages were obtained in good to excellent yields when substituted or unsubstituted α-laminaribiosyl fluorides, acting as donors, were condensed onto mono- and disaccharide β-D-hexopyranoside acceptors by using a (1,3)-β-D-glycosynthase. These linear and branched (1,3)-β-linked oligosaccharides could prove to be important in a range of medical, pharmaceutical, and agricultural applications. Furthermore, the observation that the (1,3)-β-D-glucan glycosynthase accommodates (1,3)-, (1,4), - and (1,6)-β-oligosaccharides in its acceptor subsites suggests novel, yet unexpected physiological roles for the wild type (1,3)-β-D-glucan endohydrolase from higher plants. |
Keywords: | Carbohydrates enzymatic synthesis glycosides glycosynthase oligosaccharides |
DOI: | 10.1002/chem.200304733 |
Published version: | http://dx.doi.org/10.1002/chem.200304733 |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 6 |
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