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Type: Book chapter
Title: Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types
Author: Mrozik, K.
Xiong, J.
Zilm, P.
Gronthos, S.
Bartold, P.
Citation: Stem cells and cancer stem cells: Therapeutic applications in disease and injury. Volume 4, 2012 / Hayat, M. (ed./s), Ch.24, pp.267-284
Publisher: Springer
Issue Date: 2012
Series/Report no.: Stem cells and cancer stem cells; vol. 4
ISBN: 9789400728288
Statement of
Krzysztof M. Mrozik, Jimin Xiong, Peter S. Zilm, Stan Gronthos and P. Mark Bartold
Abstract: The evolution of proteomics has led to its application in identifying biomarkers of biological processes and pathways including signal transduction and cell development. Proteomic technologies are increasingly utilized to define the molecular mechanisms controlling mesenchymal stem/stromal cell (MSC) self-renewal, multipotency and fate. Bone marrow-derived MSCs are highly promising candidates in the field of regenerative medicine based on their high proliferative capacity, multi-lineage differentiation potential and immunomodulatory properties. Recently, equivalent MSC-like populations have also been isolated from adipose, dental and feto-maternal tissues. This chapter discusses the current technologies available for proteomic analysis and the studies performed on tissue-specific MSC-like populations to date.
Keywords: Proteomics; mesenchymal stem cells; mass spectrometry; differentiation; regeneration
Description: Also published in: Stem cells and cancer stem cells: Therapeutic applications in disease and injury. Volume 3, 2012 / Hayat, M.A. (ed./s), pp.75-94
Rights: © Springer Science+Business Media B.V. 2012
RMID: 0030076810
DOI: 10.1007/978-94-007-2828-8_24
Appears in Collections:Dentistry publications

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