Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/109837
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Type: Journal article
Title: Comparison of protective immune responses to apicomplexan parasites
Author: Frölich, S.
Entzeroth, R.
Wallach, M.
Citation: Journal of Parasitology Research, 2012; 2012:852591-1-852591-11
Publisher: Hindawi Publishing Corporation
Issue Date: 2012
ISSN: 2090-0023
2090-0031
Statement of
Responsibility: 
Sonja Frölich, Rolf Entzeroth and Michael Wallach
Abstract: Members of the phylum Apicomplexa, which includes the species Plasmodium, Eimeria, Toxoplasma, and Babesia amongst others, are the most successful intracellular pathogens known to humankind. The widespread acquisition of antimicrobial resistance to most drugs used to date has sparked a great deal of research and commercial interest in the development of vaccines as alternative control strategies. A few antigens from the asexual and sexual stages of apicomplexan development have been identified and their genes characterised; however, the fine cellular and molecular details of the effector mechanisms crucial for parasite inhibition and stimulation of protective immunity are still not entirely understood. This paper provides an overview of what is currently known about the protective immune response against the various types of apicomplexan parasites and focuses mainly on the similarities of these pathogens and their host interaction. Finally, the evolutionary relationships of these parasites and their hosts, as well as the modulation of immune functions that are critical in determining the outcome of the infection by these pathogenic organisms, are discussed.
Rights: Copyright © 2012 Sonja Frölich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030045925
DOI: 10.1155/2012/852591
Appears in Collections:Medicine publications

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