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Type: Journal article
Title: Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals
Author: Su, Y.
Chen, K.
Hassanshahi, M.
Tang, Q.
Howe, P.
Xian, C.
Citation: Annals of the New York Academy of Sciences, 2017; 1403(1):109-117
Publisher: Wiley
Issue Date: 2017
ISSN: 0077-8923
Statement of
Yu-Wen Su, Ke-Ming Chen, Mohammadhossein Hassanshahi, Qian Tang, Peter R. Howe and Cory J. Xian
Abstract: Intensive cancer chemotherapy causes significant bone loss, for which the mechanisms remain unclear and effective treatments are lacking. This is a significant issue particularly for childhood cancers, as the most common ones have a >75% cure rate following chemotherapy; there is an increasing population of survivors who live with chronic bone defects. Studies suggest that these defects are the result of reduced bone from increased marrow fat formation and increased bone resorption following chemotherapy. These changes probably result from altered expression/activation of regulatory molecules or pathways regulating skeletal cell formation and activity. Treatment with methotrexate, an antimetabolite commonly used in childhood oncology, has been shown to increase levels of proinflammatory/pro-osteoclastogenic cytokines (e.g., enhanced NF-κB activation), leading to increased osteoclast formation and bone resorption, as well as to attenuate Wnt signaling, leading to both decreased bone and increased marrow fat formation. In recent years, understanding the mechanisms of action and potential health benefits of selected nutraceuticals, including resveratrol, genistein, icariin, and inflammatory fatty acids, has led to preclinical studies that, in some cases, indicate efficacy in reducing chemotherapy-induced bone defects. We summarize the supporting evidence.
Keywords: Bone loss; cancer chemotherapy; flavonoids; fish oil; bone cell
Rights: © 2017 New York Academy of Sciences.
RMID: 0030075383
DOI: 10.1111/nyas.13380
Appears in Collections:Medicine publications

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