Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/110989
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Antecedent hypoglycemia does not attenuate the acceleration of gastric emptying by hypoglycemia |
Author: | Kar, P. Jones, K.L. Plummer, M.P. Ali Abdelhamid, Y. Giersch, E. Summers, M.J. Hatzinikolas, S. Heller, S. Horowitz, M. Deane, A.M. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2017; 102(11):3953-3960 |
Publisher: | The Endocrine Society |
Issue Date: | 2017 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | Palash Kar, Karen L Jones, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Seva Hatzinikolas, Simon Heller, Michael Horowitz, Adam M Deane |
Abstract: | Context: Acute hypoglycemia accelerates gastric emptying and increases cardiac contractility. However, antecedent hypoglycemia attenuates counterregulatory hormonal responses to subsequent hypoglycemia. Objective: To determine the effect of antecedent hypoglycemia on gastric and cardiac responses to subsequent hypoglycemia in health. Design: A prospective, single-blind, randomized, crossover study (performed at the Royal Adelaide Hospital, Adelaide, South Australia, Australia). Patients: Ten healthy young men 18 to 35 years of age were studied for 36 hours on two occasions. Interventions: Participants were randomly assigned to either antecedent hypoglycemia [three 45-minute periods of strict hypoglycemia (2.8 mmol/L] or control [three 45-minute periods of strict euglycemia (6 mmol/L)] during the initial 12-hour period. Participants were monitored overnight, and the following morning blood glucose was clamped at 2.8 mmol/L for 60 minutes and then at 6 mmol/L for 120 minutes. At least 6 weeks later participants returned for the alternative intervention. Gastric emptying and cardiac fractional shortening were measured with scintigraphy and two-dimensional echocardiography, respectively, on the morning of all 4 study days. Results: A single, acute episode of hypoglycemia accelerated gastric emptying (P = 0.01) and augmented fractional shortening (P < 0.01). Gastric emptying was unaffected by antecedent hypoglycemia (P = 0.74) whereas fractional shortening showed a trend to attenuation (P = 0.06). The adrenaline response was diminished (P < 0.05) by antecedent hypoglycemia Conclusions: In health, the acceleration of gastric emptying during hypoglycemia is unaffected by antecedent hypoglycemia, whereas the increase in cardiac contractility may be attenuated. |
Keywords: | Diabetes; pancreatic and gastrointestinal hormones |
Rights: | © 2017 Endocrine Society |
DOI: | 10.1210/jc.2017-00051 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1210/jc.2017-00051 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.