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https://hdl.handle.net/2440/110989
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dc.contributor.author | Kar, P. | - |
dc.contributor.author | Jones, K.L. | - |
dc.contributor.author | Plummer, M.P. | - |
dc.contributor.author | Ali Abdelhamid, Y. | - |
dc.contributor.author | Giersch, E. | - |
dc.contributor.author | Summers, M.J. | - |
dc.contributor.author | Hatzinikolas, S. | - |
dc.contributor.author | Heller, S. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Deane, A.M. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2017; 102(11):3953-3960 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | http://hdl.handle.net/2440/110989 | - |
dc.description.abstract | Context: Acute hypoglycemia accelerates gastric emptying and increases cardiac contractility. However, antecedent hypoglycemia attenuates counterregulatory hormonal responses to subsequent hypoglycemia. Objective: To determine the effect of antecedent hypoglycemia on gastric and cardiac responses to subsequent hypoglycemia in health. Design: A prospective, single-blind, randomized, crossover study (performed at the Royal Adelaide Hospital, Adelaide, South Australia, Australia). Patients: Ten healthy young men 18 to 35 years of age were studied for 36 hours on two occasions. Interventions: Participants were randomly assigned to either antecedent hypoglycemia [three 45-minute periods of strict hypoglycemia (2.8 mmol/L] or control [three 45-minute periods of strict euglycemia (6 mmol/L)] during the initial 12-hour period. Participants were monitored overnight, and the following morning blood glucose was clamped at 2.8 mmol/L for 60 minutes and then at 6 mmol/L for 120 minutes. At least 6 weeks later participants returned for the alternative intervention. Gastric emptying and cardiac fractional shortening were measured with scintigraphy and two-dimensional echocardiography, respectively, on the morning of all 4 study days. Results: A single, acute episode of hypoglycemia accelerated gastric emptying (P = 0.01) and augmented fractional shortening (P < 0.01). Gastric emptying was unaffected by antecedent hypoglycemia (P = 0.74) whereas fractional shortening showed a trend to attenuation (P = 0.06). The adrenaline response was diminished (P < 0.05) by antecedent hypoglycemia Conclusions: In health, the acceleration of gastric emptying during hypoglycemia is unaffected by antecedent hypoglycemia, whereas the increase in cardiac contractility may be attenuated. | - |
dc.description.statementofresponsibility | Palash Kar, Karen L Jones, Mark P Plummer, Yasmine Ali Abdelhamid, Emma J Giersch, Matthew J Summers, Seva Hatzinikolas, Simon Heller, Michael Horowitz, Adam M Deane | - |
dc.language.iso | en | - |
dc.publisher | The Endocrine Society | - |
dc.rights | © 2017 Endocrine Society | - |
dc.source.uri | http://dx.doi.org/10.1210/jc.2017-00051 | - |
dc.subject | Diabetes; pancreatic and gastrointestinal hormones | - |
dc.title | Antecedent hypoglycemia does not attenuate the acceleration of gastric emptying by hypoglycemia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/jc.2017-00051 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Jones, K.L. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Plummer, M.P. [0000-0002-9640-1911] | - |
dc.identifier.orcid | Ali Abdelhamid, Y. [0000-0002-3340-1965] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Deane, A.M. [0000-0002-7620-5577] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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