Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111051
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dc.contributor.authorGrzeskowiak, L.en
dc.contributor.authorLeggett, C.en
dc.contributor.authorCosti, L.en
dc.contributor.authorRoberts, C.en
dc.contributor.authorAmir, L.en
dc.date.issued2018en
dc.identifier.citationBritish Journal of Clinical Pharmacology, 2018; 84(6):1373-1379en
dc.identifier.issn0306-5251en
dc.identifier.issn1365-2125en
dc.identifier.urihttp://hdl.handle.net/2440/111051-
dc.description.abstractAims: To examine the association between late pregnancy exposure to serotonin reuptake inhibitor (SRI) antidepressants and difficulties in achieving an adequate breast milk supply in women who gave birth to preterm infants, while accounting for the potential impacts of underlying maternal psychiatric illness. Methods: Retrospective cohort study of 3,024 women delivering liveborn preterm infants (<37 weeks' gestation) between January 2004 and December 2008. The primary outcome was postnatal domperidone use, considered a valid proxy for presence and pharmacological management of low milk supply. Relative risks adjusted for maternal soiodemographics and comorbidities (aRRs) were calculated for low milk supply, comparing women with late pregnancy exposure to SRI antidepressants (n = 86), women with a psychiatric illness but no antidepressant use (n = 126), and women with neither antenatal exposures (n = 2 812). Results: Compared to non-exposed women, non-medicated psychiatric illness (aRR 1.64; 95%CI 1.16-2.30) but not late pregnancy SRI use (aRR 1.00; 95%CI 0.59-1.70) was associated with an increased risk of domperidone use, indicative of low milk supply. Conclusions: These findings do not support the previously observed negative impacts of antidepressant use on breastfeeding, instead suggesting that women with an underlying psychiatric illness appear at greatest risk of experiencing low milk supply and could benefit from additional breastfeeding education and support.en
dc.description.statementofresponsibilityLuke E Grzeskowiak, Catherine Leggett, Lynn Costi, Claire T Roberts, Lisa H Amiren
dc.language.isoenen
dc.publisherWiley/Blackwellen
dc.rights© 2018 The British Pharmacological Societyen
dc.subjectserotonin agents; antidepressive agents; breastfeeding; lactation; premature birthen
dc.titleImpact of serotonin reuptake inhibitor use on breast milk supply in mothers of preterm infants: a retrospective cohort studyen
dc.typeJournal articleen
dc.identifier.rmid0030083685en
dc.identifier.doi10.1111/bcp.13575en
dc.identifier.pubid399874-
pubs.library.collectionPaediatrics publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGrzeskowiak, L. [0000-0001-8554-4696]en
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
Appears in Collections:Paediatrics publications

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