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|dc.identifier.citation||Heart, 2013; 99(8):542-547||en|
|dc.description.abstract||Objective: We examined cognitive function in older hospitalised patients with chronic atrial fibrillation (AF). Design: A prospective substudy of a multicentre randomised trial of an AF-specific disease management intervention (the Standard versus Atrial Fibrillation spEcific managemenT studY; SAFETY). Setting: Three tertiary referral hospitals within Australia. Patients: A total of 260 patients with chronic AF: mean age 72±11 years, 53% men, mean CHA2DS2-VASc score 4±2. Interventions: Cognitive function was assessed at baseline (during inpatient stay) using the Montreal Cognitive Assessment (MoCA).Main Outcome Measures: The extent of mild cognitive impairment (MCI-defined as a MoCA score <26) in AF patients and identification of independent predictors of MCI. Results: Overall, 169 patients (65%, 95% CI 59% to 71%) were found to have MCI at baseline (mean MoCA score 21±3). Multiple deficits in cognitive domains were identified, most notably in executive functioning, visuospatial abilities and short-term memory. Predictors of MCI (age and sex-adjusted) were lower education level (technical/trade school level OR 6.00, 95% CI 2.07 to 17.42; <8 years school education OR 5.29, 95% CI 1.95 to 14.36 vs 8-13 years), higher CHA2DS2-VASc score (OR 1.46, 95% CI 1.23 to 1.74) and prescribed digoxin (OR 2.19, 95% CI 1.17 to 4.10). Conclusions: MCI is highly prevalent amongst typically older high-risk patients hospitalised with AF. Routine assessment of cognitive function with adjustment of clinical management is indicated for this patient group.||en|
|dc.description.statementofresponsibility||Jocasta Ball, Melinda Jane Carrington, Simon Stewart, on behalf of the SAFETY investigators||en|
|dc.publisher||BMJ Publishing Group||en|
|dc.rights||Copyright © 2013, BMJ Publishing Group Ltd and the British Cardiovascular Society||en|
|dc.subject||Atrial Fibrillation; cognitive dysfunction||en|
|dc.title||Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?||en|
|dc.identifier.orcid||Stewart, S. [0000-0001-9032-8998]||en|
|Appears in Collections:||Medicine publications|
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