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Type: Journal article
Title: Hypertriglyceridemia and cardiovascular diseases: revisited
Author: Han, S.
Nicholls, S.
Sakuma, I.
Zhao, D.
Koh, K.
Citation: Korean Circulation Journal, 2016; 46(2):135-144
Publisher: Korean Society of Cardiology
Issue Date: 2016
ISSN: 1738-5520
Statement of
Seung Hwan Han, Stephen J Nicholls, Ichiro Sakuma, Dong Zhao and Kwang Kon Koh
Abstract: Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia.
Keywords: Residual cardiovascular risk; hypertriglyceridemia; treatment; cardiovascular disease
Rights: Copyright © 2016 The Korean Society of Cardiology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030049647
DOI: 10.4070/kcj.2016.46.2.135
Appears in Collections:Medicine publications

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