Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113605
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Type: | Journal article |
Title: | Hypertriglyceridemia and cardiovascular diseases: revisited |
Author: | Han, S. Nicholls, S. Sakuma, I. Zhao, D. Koh, K. |
Citation: | Korean circulation journal, 2016; 46(2):135-144 |
Publisher: | Korean Society of Cardiology |
Issue Date: | 2016 |
ISSN: | 1738-5520 1738-5555 |
Statement of Responsibility: | Seung Hwan Han, Stephen J Nicholls, Ichiro Sakuma, Dong Zhao and Kwang Kon Koh |
Abstract: | Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid profiles and cardiovascular outcomes. In this review, we will discuss the role of hypertriglyceridemia, triglyceride-rich lipoproteins and remnant cholesterol on cardiovascular disease, and the potential implications for treatment stargeting hypertriglyceridemia. |
Keywords: | Residual cardiovascular risk; hypertriglyceridemia; treatment; cardiovascular disease |
Rights: | Copyright © 2016 The Korean Society of Cardiology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.4070/kcj.2016.46.2.135 |
Published version: | http://dx.doi.org/10.4070/kcj.2016.46.2.135 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_113605.pdf | Published Version | 406.5 kB | Adobe PDF | View/Open |
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