Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113608
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dc.contributor.authorGaskin, S.en
dc.contributor.authorHeath, L.en
dc.contributor.authorPisaniello, D.en
dc.contributor.authorEvans, R.en
dc.contributor.authorEdwards, J.en
dc.contributor.authorLogan, M.en
dc.contributor.authorBaxter, C.en
dc.date.issued2017en
dc.identifier.citationToxicology and Industrial Health, 2017; 33(4):289-296en
dc.identifier.issn0748-2337en
dc.identifier.issn1477-0393en
dc.identifier.urihttp://hdl.handle.net/2440/113608-
dc.description.abstractAccidental or intentional releases of toxic gases can have significant public health consequences and emergency resource demands. Management of exposed individuals during hazardous material incidents should be risk and evidence based, but there are knowledge gaps in relation to dermal absorption of gases and management advice for potentially exposed individuals. Using a modified Organization for Economic Co-operation and Development (OECD) in vitro toxicology protocol with human donor skin, this article reports on two common and odorous chemicals, hydrogen sulphide and phosphine. Results show that undamaged human skin provides a good barrier to hydrogen sulphide (up to 800 ppm) and phosphine (up to 1000 ppm) penetration for up to 30 min exposures, with little variability in the presence of clothing or in elevated temperature and humidity conditions. A practical guideline template for skin decontamination has been developed, and implications of the research for first responders are outlined.en
dc.description.statementofresponsibilitySharyn Gaskin, Linda Heath, Dino Pisaniello, Richard Evans, John W Edwards, Michael Logan and Christina Baxteren
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.rights© The Author(s) 2016 Reprints and permissions: sagepub.co.uk/journalsPermissions.naven
dc.subjectDermal; vapour; emergency response; phosphine; hydrogen sulphideen
dc.titleHydrogen sulphide and phosphine interactions with human skin in vitro: Application to hazardous material incident decision making for skin decontaminationen
dc.typeJournal articleen
dc.identifier.rmid0030045053en
dc.identifier.doi10.1177/0748233716630646en
dc.identifier.pubid239414-
pubs.library.collectionPublic Health publicationsen
pubs.library.teamDS14en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGaskin, S. [0000-0002-1507-6425]en
dc.identifier.orcidPisaniello, D. [0000-0002-4156-0608]en
dc.identifier.orcidEdwards, J. [0000-0001-5265-3570]en
Appears in Collections:Public Health publications

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