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https://hdl.handle.net/2440/11389
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Type: | Journal article |
Title: | Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16 |
Author: | Cavanaugh, J. Callen, D. Wilson, S. Stanford, P. Sraml, M. Gorska, M. Crawford, J. Whitmore, S. Shlegel, C. Foote, S. Kohonen-Corish, M. Pavli, P. |
Citation: | Annals of Human Genetics, 1998; 62(4):291-298 |
Publisher: | WILEY |
Issue Date: | 1998 |
ISSN: | 0003-4800 1469-1809 |
Abstract: | A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753. |
Keywords: | Chromosomes, Human, Pair 16 Humans Inflammatory Bowel Diseases Crohn Disease Genetic Predisposition to Disease Chromosome Mapping Pedigree Genotype Haplotypes Lod Score Australia Female Male Genetic Linkage |
Rights: | © 1998 University College London |
DOI: | 10.1046/j.1469-1809.1998.6240291.x |
Published version: | http://dx.doi.org/10.1046/j.1469-1809.1998.6240291.x |
Appears in Collections: | Aurora harvest 2 Genetics publications |
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