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Type: Journal article
Title: Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
Author: Cleton-Jansen, A.
Moerland, E.
Pronk, J.
Van Berkel, C.
Apostolou, S.
Crawford, J.
Savoia, A.
Auerbach, A.
Callen, D.
Cornelisse, C.
Citation: British Journal of Cancer, 1999; 79(7-8):1049-1052
Publisher: Nature Publishing Group
Issue Date: 1999
ISSN: 0007-0920
Statement of
A-M Cleton-Jansen, EW Moerland, JC Pronk, CGM van Berkel, S Apostolou, J Crawford, A Savoia, AD Auerbach, CG Mathew, DF Callen and CJ Cornelisse
Abstract: The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.
Keywords: Chromosomes, Human, Pair 16; Humans; Breast Neoplasms; Proteins; Cell Cycle Proteins; DNA-Binding Proteins; Nuclear Proteins; DNA Mutational Analysis; Loss of Heterozygosity; Polymorphism, Single-Stranded Conformational; Genes, Tumor Suppressor; Female; Fanconi Anemia Complementation Group Proteins
Description: Article no. bjoc.1998.0168
Provenance: Published online 12 February 1999
Rights: Copyright © 1999 Cancer Research Campaign
RMID: 0030004341
DOI: 10.1038/sj.bjc.6690168
Appears in Collections:Genetics publications

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