Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/11445
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers Syndrome. |
Author: | Kortschak, R. Reimann, H. Zimmer, M. Eyre, H. Saint, R. Jenne, D. |
Citation: | Genomics, 1998; 51(2):288-292 |
Publisher: | ACADEMIC PRESS INC |
Issue Date: | 1998 |
ISSN: | 0888-7543 1089-8646 |
Statement of Responsibility: | R. Daniel Kortschak, Heike Reimann, Michael Zimmer, Helen J. Eyre, Robert Saint and Dieter E. Jenne |
Abstract: | The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder. |
Keywords: | Hela Cells Chromosomes, Human, Pair 19 Animals Humans Drosophila Peutz-Jeghers Syndrome DNA-Binding Proteins Homeodomain Proteins Trans-Activators Drosophila Proteins Nuclear Proteins Transcription Factors DNA, Complementary RNA, Messenger Chromosome Mapping Cloning, Molecular Pedigree Sequence Analysis, DNA Phylogeny Organ Specificity Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Genes, Regulator Oncogenes Introns Exons Molecular Sequence Data Male |
Rights: | Copyright © 1998 Academic Press |
DOI: | 10.1006/geno.1998.5259 |
Published version: | http://dx.doi.org/10.1006/geno.1998.5259 |
Appears in Collections: | Aurora harvest 2 Genetics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.