Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/11445
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Type: Journal article
Title: The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers Syndrome.
Author: Kortschak, R.
Reimann, H.
Zimmer, M.
Eyre, H.
Saint, R.
Jenne, D.
Citation: Genomics, 1998; 51(2):288-292
Publisher: ACADEMIC PRESS INC
Issue Date: 1998
ISSN: 0888-7543
1089-8646
Statement of
Responsibility: 
R. Daniel Kortschak, Heike Reimann, Michael Zimmer, Helen J. Eyre, Robert Saint and Dieter E. Jenne
Abstract: The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder.
Keywords: Hela Cells
Chromosomes, Human, Pair 19
Animals
Humans
Drosophila
Peutz-Jeghers Syndrome
DNA-Binding Proteins
Homeodomain Proteins
Trans-Activators
Drosophila Proteins
Nuclear Proteins
Transcription Factors
DNA, Complementary
RNA, Messenger
Chromosome Mapping
Cloning, Molecular
Pedigree
Sequence Analysis, DNA
Phylogeny
Organ Specificity
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Genes, Regulator
Oncogenes
Introns
Exons
Molecular Sequence Data
Male
Rights: Copyright © 1998 Academic Press
DOI: 10.1006/geno.1998.5259
Published version: http://dx.doi.org/10.1006/geno.1998.5259
Appears in Collections:Aurora harvest 2
Genetics publications

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