Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114525
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Type: Journal article
Title: High rate of translocation-based gene birth on the Drosophila Y chromosome
Author: Tobler, R.
Nolte, V.
Schlötterer, C.
Citation: Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(44):11721-11726
Publisher: National Academy of Sciences
Issue Date: 2017
ISSN: 0027-8424
1091-6490
Statement of
Responsibility: 
Ray Tobler, Viola Nolte and Christian Schlötterer
Abstract: The Y chromosome is a unique genetic environment defined by a lack of recombination and male-limited inheritance. The Drosophila Y chromosome has been gradually acquiring genes from the rest of the genome, with only seven Y-linked genes being gained over the past 63 million years (0.12 gene gains per million years). Using a next-generation sequencing (NGS)-powered genomic scan, we show that gene transfers to the Y chromosome are much more common than previously suspected: at least 25 have arisen across three Drosophila species over the past 5.4 million years (1.67 per million years for each lineage). The gene transfer rate is significantly lower in Drosophila melanogaster than in the Drosophila simulans clade, primarily due to Y-linked retrotranspositions being significantly more common in the latter. Despite all Y-linked gene transfers being evolutionarily recent (<1 million years old), only three showed evidence for purifying selection (ω ≤ 0.14). Thus, although the resulting Y-linked functional gene acquisition rate (0.25 new genes per million years) is double the longer-term estimate, the fate of most new Y-linked genes is defined by rapid degeneration and pseudogenization. Our results show that Y-linked gene traffic, and the molecular mechanisms governing these transfers, can diverge rapidly between species, revealing the Drosophila Y chromosome to be more dynamic than previously appreciated. Our analytical method provides a powerful means to identify Y-linked gene transfers and will help illuminate the evolutionary dynamics of the Y chromosome in Drosophila and other species.
Keywords: Y chromosome; evolution; Drosophila; retrocopies; transposition
Rights: Copyright © 2017 the Author(s). Published by PNAS. This is an open access article distributed under the PNAS license.
RMID: 0030077587
DOI: 10.1073/pnas.1706502114
Appears in Collections:Ecology, Evolution and Landscape Science publications

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