Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/114688
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Type: Journal article
Title: New biomarkers for intestinal permeability induced by lipopolysaccharide in chickens
Author: Gilani, S.
Howarth, G.
Kitessa, S.
Forder, R.
Tran, C.
Hughes, R.
Citation: Animal Production Science, 2016; 56(12):1984-1997
Publisher: CSIRO Publishing
Issue Date: 2016
ISSN: 1836-0939
1836-5787
Statement of
Responsibility: 
Saad Gilani, Gordon S. Howarth, Soressa M. Kitessa, Rebecca E.A. Forder, Cuong D. Tran and Robert J. Hughes
Abstract: Intestinal health is influenced by a complex set of variables involving the intestinal microbiota, mucosal immunity, digestion and absorption of nutrients, intestinal permeability (IP) and intestinal integrity. An increase in IP increases bacterial or toxin translocation, activates the immune system and affects health. IP in chickens is reviewed in three sections. First, intestinal structure and permeability are discussed briefly. Second, the use of lipopolysaccharide (LPS) as a tool to increase IP is discussed in detail. LPS, a glycolipid found in the outer coat of mostly Gram-negative bacteria, has been reported to increase IP in rats, mice and pigs. Although LPS has been used in chickens for inducing systemic inflammation, information regarding LPS effects on IP is limited. This review proposes that LPS could be used as a means to increase IP in chickens. The final section focuses on potential biomarkers to measure IP, proposing that the sugar-recovery method may be optimal for application in chickens.
Keywords: Anti-trypsin inhibitor; fluorescein isothiocyanate dextran; intestinal fatty acid-binding protein; lactulose; leaky gut; models
Rights: Journal compilation © CSIRO 2016
RMID: 0030058019
DOI: 10.1071/AN15725
Appears in Collections:Animal and Veterinary Sciences publications

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