Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/11563
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Dependance of epithelial growth of the small intestine on T-cell activation during weaning in the rat |
Author: | Thompson, F. Mayrhofer, G. Cummins, A. |
Citation: | Gastroenterology, 1996; 111(1):37-44 |
Publisher: | W B SAUNDERS CO |
Issue Date: | 1996 |
ISSN: | 0016-5085 1528-0012 |
Abstract: | <h4>Background & aims</h4>Intestinal crypt hyperplasia is associated with local T-cell activation in both clinical and experimental examples of immunologically mediated enteropathy. This suggests that T cell-derived factors may be trophic for epithelial proliferation in the intestine postnatally. The purpose of this study was to investigate T-cell activity during weaning in the rat and to investigate immune dependence of intestinal growth on T-cell activation.<h4>Methods</h4>The expression of interleukin-2 receptor (IL-2R) by mesenteric lymph node T cells was investigated from days 14 to 160 of life. Rats were treated with monoclonal antibodies against the IL-2R that were nonblocking (control) or blocking (experimental) from day 7, and intestinal growth was assessed at days 19, 25, and 29 of life.<h4>Results</h4>The mean +/- SEM of T cells expressing the IL-2R during weaning (days 15-28) was 6.1% +/- 0.3% compared with 3.3% +/- 0.3% at other ages (P < 0.001). The small intestine in rats treated with blocking antibody had reduced crypt length and mitotic count compared with control animals.<h4>Conclusions</h4>Weaning is associated with activation of T cells and blockade of the IL-2R reduces intestinal growth. |
Keywords: | Intestinal Mucosa Intestine, Small Epithelium T-Lymphocytes Animals Rats, Inbred Strains Rats Dermatitis, Contact Receptors, Interleukin-2 Antibodies, Monoclonal Flow Cytometry Linear Models Lymphocyte Activation Weaning Female Male |
DOI: | 10.1053/gast.1996.v111.pm8698223 |
Published version: | http://dx.doi.org/10.1053/gast.1996.v111.pm8698223 |
Appears in Collections: | Aurora harvest 7 Microbiology and Immunology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.