Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/116787
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Type: | Journal article |
Title: | Continuous-flow in-line solvent-swap crystallization of vitamin D₃ |
Other Titles: | Continuous-flow in-line solvent-swap crystallization of vitamin D(3) |
Author: | Escribà-Gelonch, M. Hessel, V. Maier, M. Noël, T. Neira D'Angelo, M. Gruber-Woelfler, H. |
Citation: | Organic Process Research and Development, 2018; 22(2):178-189 |
Publisher: | ACS Publications |
Issue Date: | 2018 |
ISSN: | 1083-6160 1520-586X |
Statement of Responsibility: | Marc Escribà-Gelonch, Volker Hessel, Manuel C. Maier, Timothy Noël, Maria Fernanda Neira d’Angelo and Heidrun Gruber-Woelfler |
Abstract: | A continuous tandem in-line evaporation–crystallization is presented. The process includes an in-line solvent-swap step, suitable to be coupled to a capillary based cooler. As a proof of concept, this setup is tested in a direct in-line acetonitrile mediated crystallization of Vitamin D₃. This configuration is suitable to be coupled to a new end-to-end continuous microflow synthesis of Vitamin D₃. By this procedure, vitamin particles can be crystallized in continuous flow and isolated using an in-line continuous filtration step. In one run in just 1 min of cooling time, ∼50% (w/w) crystals of Vitamin D₃ are directly obtained. Furthermore, the polymorphic form as well as crystals shape and size properties are described in this paper. |
Rights: | © 2017 American Chemical Society. ACS AuthorChoice - This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
DOI: | 10.1021/acs.oprd.7b00351 |
Published version: | http://dx.doi.org/10.1021/acs.oprd.7b00351 |
Appears in Collections: | Aurora harvest 3 Chemistry publications |
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hdl_116787.pdf | Published Version | 4.21 MB | Adobe PDF | View/Open |
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