Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117322
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAbell, S.en
dc.contributor.authorMousa, A.en
dc.contributor.authorJoham, A.en
dc.contributor.authorMoran, L.en
dc.contributor.authorStepto, N.en
dc.contributor.authorSpritzer, P.en
dc.contributor.authorTeede, H.en
dc.contributor.authorde Courten, B.en
dc.date.issued2018en
dc.identifier.citationJournal of Steroid Biochemistry and Molecular Biology, 2018; 177:209-215en
dc.identifier.issn0960-0760en
dc.identifier.issn1879-1220en
dc.identifier.urihttp://hdl.handle.net/2440/117322-
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS. The primary aim of this study was to compare DBP, bioavailable and free 25(OH)D concentrations in women with PCOS and controls. The secondary aim was to investigate relationships between DBP, bioavailable and free 25(OH)D and metabolic features (anthropometric measures, insulin resistance, and lipid profile). In a cross sectional study using bio-banked samples, we measured 25(OH)D, DBP and albumin. Bioavailable and free 25(OH)D were calculated using previously validated formula. BMI, body composition (dual X-ray absorptiometry, DXA), insulin resistance (homeostatic model assessment of insulin resistance (HOMA-IR)) and glucose infusion rate (GIR) from hyperinsulinaemic euglycaemic clamp and serum lipids (ELISA) were also measured in a physically and biochemically well-characterised cohort of women with and without PCOS. We studied 90 women with PCOS and 59 controls aged 18-48 years. DBP concentrations were lower in PCOS compared to controls (median [IQR]: 443.40 [314.4] vs 482.4 [156.8] μg/ml, p=0.02). No significant differences were found in bioavailable or free 25(OH)D concentrations between groups. DBP was not associated with BMI, percent body fat or markers of insulin resistance (all p>0.2). High-density lipoprotein (HDL) was the main determinant of DBP in the overall cohort (β=-0.12, p=0.02), after adjusting for covariates including PCOS/control status, age, BMI, total 25(OH)D and HOMA-IR. In PCOS, total and free 25(OH)D were related to markers of insulin resistance and lipids. Only the associations between free 25(OH)D and triglycerides (p=0.02), and HDL (p=0.03) remained significant after adjusting for age and BMI. In conclusion, women with PCOS had lower DBP, but similar bioavailable or free 25(OH)D concentrations compared to controls, independent of BMI and age. DBP was not associated with insulin resistance or BMI in PCOS. Further studies are needed to investigate the pathophysiology and clinical implications of reduced DBP in PCOS.en
dc.description.statementofresponsibilityNegar Naderpoor, Soulmaz Shorakae, Sally K. Abell, Aya Mousa, Anju E. Joham, Lisa J. Moran, Nigel K. Stepto, Poli Mara Spritzer, Helena J. Teede, Barbora de Courtenen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2017 Elsevier Ltd. All rights reserved.en
dc.subjectBioavailable 25(OH)D; Body mass index; Free 25(OH)D; Insulin resistance; Polycystic ovary syndrome; Vitamin D binding proteinen
dc.titleBioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: relationships with obesity and insulin resistanceen
dc.typeJournal articleen
dc.identifier.rmid0030094741en
dc.identifier.doi10.1016/j.jsbmb.2017.07.012en
dc.identifier.pubid431727-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidMoran, L. [0000-0001-5772-6484]en
dc.identifier.orcidTeede, H. [0000-0001-7609-577X]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.