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Type: Journal article
Title: Physiological functions of nedd4-2: lessons from knockout mouse models
Author: Manning, J.A.
Kumar, S.
Citation: Trends in Biochemical Sciences, 2018; 43(8):635-647
Publisher: Elsevier
Issue Date: 2018
ISSN: 0968-0004
Statement of
Jantina A. Manning, Sharad Kumar
Abstract: Protein modification by ubiquitination plays a key evolutionarily conserved role in regulating membrane proteins. Nedd4-2, a ubiquitin ligase, targets membrane proteins such as ion channels and transporters for ubiquitination. This Nedd4-2-mediated ubiquitination provides a crucial step in controlling the membrane availability of these proteins, thus affecting their signaling and physiological outcomes. In one well-studied example, Nedd4-2 fine-tunes the physiological function of the epithelial sodium channel (ENaC), thus modulating Na+ reabsorption by epithelia to maintain whole-body Na+ homeostasis. This review summarizes the key signaling pathways regulated by Nedd4-2 and the possible implications of such regulation in various pathologies.
Keywords: ENaC; Nedd4-2; ion channels; pathophysiology; sodium; ubiquitination
Rights: © 2018 Elsevier Ltd. All rights reserved.
RMID: 0030099296
DOI: 10.1016/j.tibs.2018.06.004
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Appears in Collections:Chemistry publications

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