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https://hdl.handle.net/2440/117364
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dc.contributor.author | Manning, J.A. | - |
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Trends in Biochemical Sciences, 2018; 43(8):635-647 | - |
dc.identifier.issn | 0968-0004 | - |
dc.identifier.issn | 1362-4326 | - |
dc.identifier.uri | http://hdl.handle.net/2440/117364 | - |
dc.description.abstract | Protein modification by ubiquitination plays a key evolutionarily conserved role in regulating membrane proteins. Nedd4-2, a ubiquitin ligase, targets membrane proteins such as ion channels and transporters for ubiquitination. This Nedd4-2-mediated ubiquitination provides a crucial step in controlling the membrane availability of these proteins, thus affecting their signaling and physiological outcomes. In one well-studied example, Nedd4-2 fine-tunes the physiological function of the epithelial sodium channel (ENaC), thus modulating Na+ reabsorption by epithelia to maintain whole-body Na+ homeostasis. This review summarizes the key signaling pathways regulated by Nedd4-2 and the possible implications of such regulation in various pathologies. | - |
dc.description.statementofresponsibility | Jantina A. Manning, Sharad Kumar | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2018 Elsevier Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.tibs.2018.06.004 | - |
dc.subject | ENaC | - |
dc.subject | Nedd4-2 | - |
dc.subject | ion channels | - |
dc.subject | pathophysiology | - |
dc.subject | sodium | - |
dc.subject | ubiquitination | - |
dc.title | Physiological functions of nedd4-2: lessons from knockout mouse models | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.tibs.2018.06.004 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1103006 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1020755 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1099307 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
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