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Type: Journal article
Title: Promotion of cell growth and adhesion of a peptide hydrogel scaffold via mTOR/cadherin signaling
Author: Wei, G.
Wang, L.
Dong, D.
Teng, Z.
Shi, Z.
Wang, K.
An, G.
Guan, Y.
Han, B.
Yao, M.
Xian, C.
Citation: Journal of Cellular Physiology, 2018; 233(2):822-829
Publisher: WILEY
Issue Date: 2018
ISSN: 0021-9541
Statement of
Guojun Wei, Liping Wang, Daming Dong, Zhaowei Teng, Zuowei Shi, Kaifu Wang, Gang An, Ying Guan, Bo Han, Meng Yao, Cory J. Xian
Abstract: Understanding neurite outgrowth, orientation, and migration is important for the design of biomaterials that interface with the neural tissue. However, the molecular signaling alternations have not been well elucidated to explain the impact of hydrogels on cell morphology. In our previous studies, a silk fibroin peptide (SF16) hydrogel was found to be an effective matrix for the viability, morphology, and proliferation of PC12 rat pheocrhomocytoma cells. We found that PC12 cells in the peptide hydrogel exhibited adhesive morphology compared to those cultured in agarose or collagen. Moreover, we identified that cell adhesion molecules (E- and N-cadherin) controlled by mTOR signaling were highly induced in PC12 cells cultured in the SF16 peptide hydrogel. Our findings suggest that the SF16 peptide might be suitable to be a cell-adhesion material in cell culture or tissue engineering, and mTOR/cadherin signaling is required for the cell adhesion in the SF16-peptide hydrogel.
Keywords: Cadherin; hydrogel; mTOR; PC12 cells; SF16 peptide
Rights: © 2017 Wiley Periodicals, Inc.
DOI: 10.1002/jcp.25864
Grant ID: 81371368
Appears in Collections:Aurora harvest 3
Zoology publications

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