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https://hdl.handle.net/2440/117435
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dc.contributor.author | Hutchison, A. | - |
dc.contributor.author | Liu, B. | - |
dc.contributor.author | Wood, R. | - |
dc.contributor.author | Vincent, A. | - |
dc.contributor.author | Thompson, C. | - |
dc.contributor.author | O Callaghan, N. | - |
dc.contributor.author | Wittert, G. | - |
dc.contributor.author | Heilbronn, L. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Obesity, 2019; 27(1):50-58 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.issn | 1930-739X | - |
dc.identifier.uri | http://hdl.handle.net/2440/117435 | - |
dc.description.abstract | Objective: This study aimed to compare intermittent fasting (IF) versus continuous energy intakes at 100% or 70% of calculated energy requirements on insulin sensitivity, cardiometabolic risk, body weight, and composition. Methods: Women with overweight (n = 88; 50 ± 1 years, BMI 32.3 ± 0.5 kg/m² ) were randomized to one of four diets (IF70, IF100, dietary restriction [DR70], or control) in a 2:2:2:1 ratio for 8 weeks. IF groups fasted for 24 hours after breakfast on three nonconsecutive days per week. All foods were provided and diets matched for macronutrient composition (35% fat, 15% protein, 50% carbohydrate). Insulin sensitivity by hyperinsulinemic-euglycemic clamp, weight, body composition, and plasma markers were assessed following a "fed" day (12-hour fast) and a 24-hour fast (IF only). Results: IF70 displayed greater reductions in weight, fat mass, total- and low-density lipoprotein cholesterol, and nonesterified fatty acids compared with DR70 and IF100 (all P ≤ 0.05). IF100 lost more weight and fat than control. However, fasting insulin was increased. There were no group differences in insulin sensitivity by clamp; however, a 24-hour fast transiently reduced insulin sensitivity. Conclusions: When prescribed at matched energy restriction, IF reduced weight and fat mass and improved total and low-density lipoprotein cholesterol more than DR. IF prescribed in energy balance did not improve health compared with other groups, despite modest weight loss. | - |
dc.description.statementofresponsibility | Amy T. Hutchison, Bo Liu, Rachel E. Wood, Andrew D. Vincent, Campbell H. Thompson, Nathan J. O’Callaghan, Gary A. Wittert and Leonie K. Heilbronn | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2018 The Obesity Society | - |
dc.source.uri | http://dx.doi.org/10.1002/oby.22345 | - |
dc.subject | Humans | - |
dc.subject | Insulin Resistance | - |
dc.subject | Fasting | - |
dc.subject | Metabolism | - |
dc.subject | Energy Intake | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Overweight | - |
dc.title | Effects of intermittent versus continuous energy intakes on insulin sensitivity and metabolic risk in women with overweight | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/oby.22345 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1023401 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT120100027 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hutchison, A. [0000-0002-6393-3671] | - |
dc.identifier.orcid | Liu, B. [0000-0003-3101-650X] | - |
dc.identifier.orcid | Wood, R. [0000-0003-0208-6330] | - |
dc.identifier.orcid | Vincent, A. [0000-0002-6428-1070] | - |
dc.identifier.orcid | Thompson, C. [0000-0002-5164-3327] | - |
dc.identifier.orcid | Wittert, G. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Heilbronn, L. [0000-0003-2106-7303] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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