Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/117486
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Type: Journal article
Title: Exploring the modulation of hypoxia-inducible factor (HIF)-1α by volatile anesthetics as a possible mechanism underlying volatile anesthetic-induced CNS injury
Other Titles: Exploring the modulation of hypoxia-inducible factor (HIF)-1alpha by volatile anesthetics as a possible mechanism underlying volatile anesthetic-induced CNS injury
Author: Giles, E.K.
Lawrence, A.J.
Duncan, J.R.
Citation: Neurochemical Research, 2014; 39(9):1640-1647
Publisher: Springer
Issue Date: 2014
ISSN: 0364-3190
1573-6903
Statement of
Responsibility: 
Emma K. Giles, Andrew J. Lawrence, Jhodie R. Duncan
Abstract: This review summarizes recent research on the potential cognitive and behavioural abnormalities induced by exposure to volatile anesthetics and suggests a role of hypoxia-inducible factor (HIF)-1α in mediating these events. Volatile anesthetics are widely utilized in clinical and research settings, yet the long-term safety of exposure to these agents is under debate. Findings from various animal models suggest volatile anesthetics induce widespread apoptosis in the central nervous system (CNS) that correlates with lasting deficits in learning and memory. Longitudinal analysis of clinical data highlight an increased risk of developmental disorders later in life when children are exposed to volatile anesthetics, particularly when exposures occur over multiple sessions. However, the mechanisms underlying these events have yet to be established. Considering the extensive use of volatile anesthetics, it is crucial that these events are better understood. The possible role of HIF-1α in volatile anesthetic-induced CNS abnormalities will be suggested and areas requiring urgent attention will be outlined.
Keywords: Apoptosis; hypoxia; isoflurane; sevoflurane
Rights: © Springer Science+Business Media New York 2014
RMID: 0030084259
DOI: 10.1007/s11064-014-1379-y
Appears in Collections:Medicine publications

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